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IGF1 — MBP
Text-mined interactions from Literome
Ye et al., Brain Res Dev Brain Res 2002
:
To evaluate myelination we investigated
IGF-I stimulated expression of
myelin basic protein (MBP) and proteolipid protein (PLP) in the cerebral cortex CTX and brainstem, and found similar increases in each region in IRS-1 ( -/- ) and wild type mice ... In studies using mixed glial cultures derived from IRS-1 ( -/- ) mice,
IGF-I also
increased the abundance of
MBP and PLP mRNA
Palacios et al., Brain Res 2007
:
The stimulatory
effect of
insulin-like growth factor I (IGF-I) on
myelin basic protein (MBP) expression, a parameter for oligodendrocyte development, is mediated by the MAPK and PI3K signaling pathways ... We have previously shown that the second messenger cAMP inhibits
IGF-I induced MAPK activation as well as
MBP expression ... We also showed that the PKA inhibitor Rp-cAMPS reverted the cAMP effect on
IGF-I induced
MBP without affecting the cAMP effect on IGF-I induced MAPK activation ... Here we report that, in contrast to Rp-cAMPS, H89 ( a PKA inhibitor structurally non related to Rp-cAMPS ) enhances both the inhibitory effect of cAMP on
IGF-I induced
MBP expression and the inhibitory effect of cAMP on IGF-I induced MAPK activation
Cui et al., J Neuropathol Exp Neurol 2010
:
By contrast, most adult OPCs were O4 positive and Olig2 positive in defined medium ; both brain derived neurotrophic
factor/insulin-like growth factor 1 and platelet derived growth factor-AA/basic fibroblast growth factor
promoted their
myelin basic protein expression and membrane sheet formation ; coculture with dorsal root ganglion neurons further increased myelin basic protein expression
Galvin et al., J Neurosci Res 2010
:
Pharmacological inhibition of MAPK signaling also prevented
IGF-1 induced increases in
myelin basic protein (MBP) , indicating that MAPK signaling was necessary to drive IGF-1 mediated enhancement of oligodendrocyte differentiation
Yao et al., Life Sci 1996
(Demyelinating Diseases...) :
Subcutaneously administered
IGF-I also
increased relative mRNA levels of
myelin basic protein (MBP) , proteolipid (PLP) and 2',3 ' cyclic nucleotide 3'-phosphodiesterase ( CNP ), thereby promoting myelin regeneration