Gene interactions and pathways from curated databases and text-mining

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MAPKAPK5 — PRKAR2A

Text-mined interactions from Literome

Kostenko et al., Cell Mol Life Sci 2011 : We identified noroxoaconitine as an ATP competitor that inhibited the catalytic activity of MK5 in vitro ( IC50 = 37.5 µM ; K(i) = 0.675 µM ) and prevented PKA induced nuclear export of MK5, a process that depends on kinase active MK5
Shiryaev et al., Journal of molecular signaling 2011 : The MAPKAPKs MK2, MK3 and MK5 are closely related, but MK2 and MK3 are the major downstream targets of the p38MAPK pathway, while MK5 can be activated by the atypical MAPK ERK3 and ERK4, protein kinase A (PKA) , and maybe p38MAPK