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MAPK3 — MAPKAPK2

Pathways - manually collected, often from reviews:

• WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling: MAPK3 → MAPKAPK2 (mim-necessary-stimulation) Engel et al., J Biol Chem 1995*
• WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling: MAPK3 → MAPKAPK2 (mim-necessary-stimulation) Engel et al., J Biol Chem 1995*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MAPK3 — MAPKAPK2 (direct interaction, protein complementation assay) Srivastav et al., Biochem J 2011
• IRef Biogrid Interaction: MAPK3 — MAPKAPK2 (direct interaction, enzymatic study) Coxon et al., Cell Signal 2003*

Text-mined interactions from Literome

Bartlett et al., J Physiol 1999 : Induction of MAPKAP kinase-2 activity was prevented by the p38 MAPK inhibitor SB 203580 ( 10 microm, 5-30 min )
Martel-Pelletier et al., Arthritis Rheum 1999 (Osteoarthritis) : Mitogen activated protein kinase and nuclear factor kappaB together regulate interleukin-17 induced nitric oxide production in human osteoarthritic chondrocytes : possible role of transactivating factor mitogen activated protein kinase activated proten kinase ( MAPKAPK )
Aicher et al., J Immunol 1999 : The p38 MAPK-specific inhibitor, SB203580, blocked CD40 induced MAPKAPK-2 activation, but did not affect activation of c-Jun N-terminal kinase
Ishizuka et al., J Immunol 2001 : Both p38 MAPK and MAPK activated protein kinase (MAPKAPK)2 were activated following Fc ( epsilon ) RI aggregation, and activation of MAPKAPK2 was almost completely inhibited by 10 microM SB203580
Matsuda et al., Cancer Res 2002 (MAP Kinase Signaling System...) : In ASPC-1, PANC-1, and T3M4 cells, PD98059 and U0126 inhibited MAPK kinase activation but not EGF stimulated mitogenesis, whereas SB203580 inhibited EGF stimulated mitogenesis, p38 MAPK activation, and MAPK activated protein kinase 2 activation, without attenuating the mitogenic effect of insulin-like growth factor 1
Fegley et al., J Surg Res 2003 : S-1-P stimulated activation of p38 ( MAPK ) that peaked at 10 min, as well as activation of MAPKAP kinase-2
Coxon et al., Cell Signal 2003 (MAP Kinase Signaling System) : MAPK activated protein kinase-2 (MK2) is activated by p38 MAPK in human neutrophils
Hu et al., J Biol Chem 2006 (MAP Kinase Signaling System) : MAPKAPK-2 , Akt2, and ezrin phosphorylation were all attenuated by p38 MAPK inhibition but were unaffected by dominant negative ezrin expression ... siRNA mediated MAPKAPK-2 knockdown inhibited phosphorylation of Akt2 and ezrin but not p38 MAPK
Su et al., Biochim Biophys Acta 2008 (MAP Kinase Signaling System) : TNF stimulation induced p38 MAPK dependent phosphorylation of MK2 and HSP27
Duraisamy et al., Expert Opin Ther Targets 2008 (Inflammation) : Mitogen activated protein kinase ( MAPK) activated protein kinase 2 (MK2 ) is activated upon stress by p38 MAPK
Dingar et al., Cell Signal 2010 (Cardiomegaly...) : Whereas MK2 and MK3 are activated by p38 MAPK , MK5 has also been shown to be activated by ERK3 and ERK4
Shiryaev et al., Journal of molecular signaling 2011 : Stimulation of the p38MAPK , but not the PKA pathway, caused activation of MK2
Anur et al., Blood 2012 (Disease Models, Animal...) : Low doses ( 50nM ) of both agents inhibited p38 MAPK dependent activation of MAPKAPK2 (MK2) and suppressed MK2 dependent TNFa production without substantially influencing TNFa gene transcription
Xu et al., PloS one 2012 (Breast Neoplasms) : PIC induced activation of p38 MAPK and MK2 was attenuated by the PKR inhibitor and the PKR siRNA, but a selective p38 MAPK inhibitor ( SB203580 ) or other MAPK inhibitors did not affect PKR activity, indicating that PKR is upstream of p38 MAPK/MK2
Huot et al., Eur J Biochem 1995 : In all cases, the induced kinase activity was entirely associated with two polypeptides of 45 kDa and 54 kDa, identified as mitogen-activated-protein kinase activated protein ( MAPKAP) kinase-2 based on its reactivation in vitro by 42/44-kDa MAP kinases, its antigenic properties and its substrate specificity
Groblewski et al., Gastroenterology 1997 : Cholecystokinin stimulated mitogen activated protein kinase activated protein ( MAPKAP) kinase 2 activity was measured after immunoprecipitation of the kinase
Komatsu et al., Arch Biochem Biophys 1997 : The protein kinase activity of GST-MAPKAPK-4 was activated by MAPK and this enabled the kinase to phosphorylate both glycogen synthase N-terminal peptide and the regulatory light chain of myosin II in vitro
Hodge et al., J Biol Chem 1998 : GH slightly increased p38 mediated mitogen activated protein kinase activated protein ( MAPKAP) kinase-2 activity, but the p38 inhibitor SB203580 did not attenuate GH-promoted Elk-1 phosphorylation
Marshall et al., J Immunol 1998 : IL-4 induced a late ( > 4-h ) increase in p38 MAPK activity and corresponding activation of its substrate MAPKAPK-2