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AKT1 — MAPKAPK2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: AKT1 — MAPKAPK2 (physical association, affinity chromatography technology) Rane et al., J Biol Chem 2001*
• IRef Hprd Interaction: AKT1 — MAPKAPK2 (in vivo) Rane et al., J Biol Chem 2001*
• IRef Hprd Interaction: AKT1 — MAPKAPK2 (in vitro) Rane et al., J Biol Chem 2001*

Text-mined interactions from Literome

Taniyama et al., Am J Physiol Cell Physiol 2004 (MAP Kinase Signaling System) : Role of p38 MAPK and MAPKAPK-2 in angiotensin II-induced Akt activation in vascular smooth muscle cells
Miller-Jensen et al., J Cell Sci 2006 : Surprisingly, further activation of Akt in Adv infected cells via insulin treatment did not significantly reduce apoptosis or MK2 activity
Zheng et al., J Biol Chem 2006 : However, MK2 is not required for the association of hsp27 with Akt
Wu et al., J Biol Chem 2007 : Here we show that loss of Akt/Hsp27 interaction by anti-Hsp27 antibody treatment resulted in loss of Akt/MK2 interaction, loss of Akt-Ser-473 phosphorylation, and induced PMN apoptosis ... Silencing Hsp27 expression inhibited Akt/MK2 interaction, inhibited Akt phosphorylation and Akt activation, and induced HK-11 cell death
Shaw et al., Biochem J 1998 : Thus the activation of PKB by oxidative stress or heat shock is mediated by PI 3-kinase and not by MAPKAP-K2