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DEPTOR — MAPKAP1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database mTOR signaling pathway:
DEPTOR (DEPTOR)
→
mTORC2/DEPTOR complex (MTOR-MLST8-MAPKAP1-DEPTOR-RICTOR-PRR5)
(modification, collaborate)
Huang et al., Mol Cell Biol 2008, Peterson et al., Cell 2009
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database mTOR signaling pathway:
DEPTOR (DEPTOR)
→
mTORC2 complex (MTOR-MLST8-RICTOR-MAPKAP1-PRR5)
(modification, collaborate)
Huang et al., Mol Cell Biol 2008, Peterson et al., Cell 2009
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database mTOR signaling pathway:
mTORC2/DEPTOR complex (MTOR-MLST8-MAPKAP1-DEPTOR-RICTOR-PRR5)
→
mTORC2 complex (MTOR-MLST8-RICTOR-MAPKAP1-PRR5)
(modification, collaborate)
Huang et al., Mol Cell Biol 2008, Peterson et al., Cell 2009
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database mTOR signaling pathway:
mTORC2/DEPTOR complex (MTOR-MLST8-MAPKAP1-DEPTOR-RICTOR-PRR5)
→
TSC1/TSC2 complex (TSC1-TSC2)
(modification, collaborate)
Huang et al., Mol Cell Biol 2008, Peterson et al., Cell 2009
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database mTOR signaling pathway:
RICTOR (RICTOR)
→
mTORC2/DEPTOR complex (MTOR-MLST8-MAPKAP1-DEPTOR-RICTOR-PRR5)
(modification, collaborate)
Fang et al., Science 2001, Toschi et al., Mol Cell Biol 2009
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database mTOR signaling pathway:
RICTOR (RICTOR)
→
mTOR/GBL/SIN1/PROTOR1/DEPTOR complex (MTOR-MLST8-DEPTOR-MAPKAP1-PRR5)
(modification, collaborate)
Fang et al., Science 2001, Toschi et al., Mol Cell Biol 2009
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database mTOR signaling pathway:
mTORC2/DEPTOR complex (MTOR-MLST8-MAPKAP1-DEPTOR-RICTOR-PRR5)
→
mTOR/GBL/SIN1/PROTOR1/DEPTOR complex (MTOR-MLST8-DEPTOR-MAPKAP1-PRR5)
(modification, collaborate)
Fang et al., Science 2001, Toschi et al., Mol Cell Biol 2009
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database mTOR signaling pathway:
None
→
mTOR/GBL/SIN1/PROTOR1/DEPTOR complex (MTOR-MLST8-DEPTOR-MAPKAP1-PRR5)
(modification, activates)
Fang et al., Science 2001, Toschi et al., Mol Cell Biol 2009
Evidence: mutant phenotype, physical interaction
Text-mined interactions from Literome
Zhao et al., Mol Cell 2011
:
DEPTOR , an
inhibitor of mTORC1 and
mTORC2 , is degraded via ubiquitin-proteasome pathway by an unknown E3 ubiquitin ligase
Zhao et al., Neoplasia (New York, N.Y.) 2012
(Neoplasms) :
Recently, we and others found that
DEPTOR , a naturally occurring
inhibitor of both mTORC1 and
mTORC2 , was degraded by SCF ( Skp1-Cullin-F box proteins ) E3 ubiquitin ligase, the founding member of cullin-RING-ligases ( CRLs ), resulting in mTOR activation and cell proliferation