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AKT1 — MAPK8IP1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MAPK8IP1 — AKT1 (physical association, affinity chromatography technology) Song et al., J Cell Biol 2005*
• IRef Biogrid Interaction: MAPK8IP1 — AKT1 (physical association, affinity chromatography technology) Kim et al., Neuron 2002*
• IRef Hprd Interaction: AKT1 — MAPK8IP1 (in vivo) Kim et al., Neuron 2002*
• IRef Innatedb Interaction: MAPK8IP1 — AKT1 (unknown, -) Song et al., J Cell Biol 2005*
• IRef Ophid Interaction: MAPK8IP1 — AKT1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Kim et al., J Biol Chem 2003 : JNK interacting protein 1 promotes Akt1 activation ... Here we have investigated the possibility that JIP1 may also affect the catalytic activity of Akt1 , a serine/threonine kinase that has been implicated in multiple cellular processes, including survival and proliferation ... JIP1 expression enhanced Akt1 kinase activity in a dose dependent manner following serum starvation in 293 cells ... The mechanism of JIP1 mediated Akt1 activation involved JIP1 protein binding to the Akt1 pleckstrin homology domain, which in turn promoted the phosphorylation of the activation T-loop of Akt1 by phosphoinositide dependent kinase-1
Song et al., J Cell Biol 2005 (MAP Kinase Signaling System) : The JNK2 mediated phosphorylation of JIP1 results in the dissociation of Akt1 from JIP1 and subsequently restores Akt1 enzyme activity