Gene interactions and pathways from curated databases and text-mining

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MAPK4 — NOS1

Text-mined interactions from Literome

Nandan et al., Infect Immun 1999 : Activation of phosphotyrosine phosphatase activity attenuates mitogen activated protein kinase signaling and inhibits c-FOS and nitric oxide synthase expression in macrophages infected with Leishmania donovani
Xu et al., Life Sci 2000 (Glioma...) : P38 MAPK , but not p42/p44 MAPK mediated inducible nitric oxide synthase expression in C6 glioma cells
Fabrizi et al., J Biol Chem 2001 : The stimulation of inducible nitric-oxide synthase by the prion protein fragment 106 -- 126 in human microglia is tumor necrosis factor-alpha dependent and involves p38 mitogen activated protein kinase
Krainock et al., J Neurochem 2001 : Regulation of functional nitric oxide synthase-1 expression in cerebellar granule neurons by heregulin is post-transcriptional, and involves mitogen activated protein kinase
Llansola et al., Brain Res 2002 : Activation of N-methyl-D-aspartate ( NMDA ) receptors leads to increased phosphorylation of the microtubule associated protein MAP-2 by a mechanism that involves activation of nitric oxide synthase and nitric oxide induced activation of mitogen activated protein kinase ( MAP-kinase )
Simkhovich et al., Cardiovasc Pathol 2003 (Myocardial Ischemia) : Protective genes included mitogen activated protein kinase activated protein kinase 3 ( MAPKAPK 3 ), heat shock proteins 70, 27, 22, B-crystalline, vascular endothelial growth factor, inducible nitric oxide synthase and plasminogen activator inhibitors 1 and 2
Wang et al., J Pharmacol Exp Ther 2003 : Up-regulation of endothelial nitric-oxide synthase by endothelium derived hyperpolarizing factor involves mitogen activated protein kinase and protein kinase C signaling pathways
Kitamura et al., Diabetologia 2003 : Proinsulin C-peptide increases nitric oxide production by enhancing mitogen activated protein-kinase dependent transcription of endothelial nitric oxide synthase in aortic endothelial cells of Wistar rats
Anter et al., J Biol Chem 2004 : Activation of endothelial nitric-oxide synthase by the p38 MAPK in response to black tea polyphenols
Liu et al., Neurosci Lett 2006 : It was shown that the selective inhibitor of nNOS , 7-NINA ( 7-Nitroindazole, sodium salt ) ( 25 microg, i.t. ) attenuated not only the development of morphine antinociceptive tolerance, but also the activation of p38 MAPK in the spinal microglia induced by chronic intrathecal administration of morphine
Cullen et al., Atherosclerosis 2007 : The inhibitory effect of resveratrol on 125I-MCP-1 binding to THP-1 cells and on CCR2 protein expression determined by FACS analysis was attenuated by treatment with L-NAME ( NOS inhibitor ), PD98059 ( MAPK inhibitor ) and LY294002 ( PI3K inhibitor ), whereas neither X/XO ( reactive oxygen species generator ) nor ICI182780 ( estrogen receptor antagonist ) had any effect
Johnson et al., Biol Reprod 2008 : The protection offered by the caspase 2 inhibitor occurred upstream of mitochondria, involving suppression of mitogen activated protein kinase ( MAPK) 14 activation and inducible nitric oxide synthase ( NOS2 ) induction and, in turn, suppression of cytochrome c-mediated death pathway
Zhang et al., Cardiovasc Res 2009 : The present study is designed to investigate the role of neuronal nitric oxide synthase (nNOS) in the regulation of vascular mitogen activated protein kinase ( MAPK ) activity under basal and angiotensin II (Ang II) stimulated conditions
Ralay Ranaivo et al., Brain Res 2010 (MAP Kinase Signaling System) : Albumin activated ERK1/2, p38 MAPK and JNK signaling pathways in astrocytes, and induced the production of interleukin (IL)-1beta, inducible nitric oxide (NO) synthase , the NO metabolite nitrite, and the chemokine CX3CL1 while reducing the level of S100B
Cheng et al., Br J Pharmacol 2012 (Hypotension) : Effects of a selective antagonist of Y ( 1 ) receptors, a PKC inhibitor, a PI3 kinase inhibitor, a NOS inhibitor, an endothelial NOS (eNOS)-selective inhibitor, a neuronal NOS (nNOS)-specific inhibitor or a MAPK inhibitor , on responses to microinjection of NPY into the NTS of Wistar-Kyoto rats were studied to determine the underlying mechanisms
Chrestensen et al., FEBS open bio 2012 : These observations strongly suggest a direct role for MAPK in regulation of NOS with implications for signaling pathways including angiogenesis and control of vascular tone
Nishiya et al., FEBS Lett 1997 (Glioma) : Activation of Stat1 and subsequent transcription of inducible nitric oxide synthase gene in C6 glioma cells is independent of interferon-gamma induced MAPK activation that is mediated by p21ras