Gene interactions and pathways from curated databases and text-mining

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CXCR4 — MAPK13

Text-mined interactions from Literome

Molino et al., Biochim Biophys Acta 2000 (Calcium Signaling...) : It also caused CXCR4 mediated activation of MAPK , release of PGI ( 2 ), endothelial migration, and the formation of capillary-like structures by endothelial cells in culture
van den Blink et al., J Clin Immunol 2004 (Endotoxemia) : To investigate the role of p38 mitogen activated protein kinase ( MAPK ) in the regulation of CXCR expression during an inflammatory response in vivo, 24 healthy volunteers received an intravenous injection with lipopolysaccharide (LPS) preceded ( -3 hr ) by a specific p38 MAPK inhibitor ( BIRB 796 BS ) at a high dose ( 600 mg ) or a low dose ( 50 mg ) or a placebo
Fukuda et al., Blood 2005 (Acute Disease...) : In contrast, prolonged exposure of CD34+ or Ba/F3-Flt3 cells to FL down-regulated CXCR4 expression, inhibited CXCL12 mediated phosphorylation of MAPK ( p42/p44 ), CREB, and Akt, and impaired migration toward CXCL12
Thomas et al., Gut 2008 (Carcinoma in Situ...) : Finally, we show that expression of CXCR4 in murine PanIN cells is partially dependent on mitogen activated protein kinase ( MAPK ) signalling and that the effect of CXCL12 on PanIN proliferation can be abrogated by an MAPK inhibitor
Rahimi et al., Int J Cancer 2010 (Breast Neoplasms...) : More interestingly, inhibition of p38 MAPK activity significantly reduced CXCR4 expression and inhibited the invasive potential of EGFRvIII expressing breast cancer cells, suggesting an essential role for p38 MAPK in EGFRvIII/CXCR4 induced invasion
Du et al., Hum Reprod 2012 : CsA up-regulated CXCL12 and CXCR4 expression in human first-trimester cytotrophoblast cells, but not in DSCs. Blocking the mitogen activated proteinkinase/extracellular signal regulated kinase ( MAPK/ERK1/2 ) signaling by U0126 abrogated the CsA induced increase in CXCL12 and CXCR4 expression and neutralizing antibodies to CXCL12 or CXCR4 completely inhibited the CsA induced increase in cell number, invasion and MMP-9 and MMP-2 activity of cytotrophoblast
Adams et al., Int J Cardiol 2013 : Adiponectin induced CAC migration and CXCR4-upregulation were mediated through adipo-receptor 1 (AdipoR1) and blocked by an inhibitor of PI3-kinase, p38MAP kinase and NF?b. Adipo stimulated migration of CACs, CXCR4 expression and p38MAPK-activation is impaired in patients with coronary artery disease ( CAD )