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MAPK1 — NOS1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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Gene Ontology Complexes protein complex:
protein complex complex (HSF1-TRMT112-HIST1H4A-UBQLN1-CDX2-USP28-HDAC5-CAV3-CANX-LHX1-TUBA3C-TUBA3E-PI4K2A-NR0B2-RYR2-NTRK1-MPP5-N6AMT1-STAP1-ZFP42-FADD-ATP6V0D1-PRKCDBP-AQP2-FNTB-PRPSAP2-WIPI2-CRB3-CRB2-PEX11A-LDB1-RBP4-TMEM102-GATA2-ADCY2-DZIP1-SYK-TUBB4B-PTPN11-KAT5-CEP290-SYP-ASF1B-PLEKHA2-KIF24-MYO5B-RGP1-CFTR-SPTBN5-VPS72-ACTA2-PRKCI-CNST-SNX4-GNAO1-NFKBIA-UBE2D2-EPB41-RAB5A-GLUL-BSND-GSK3B-SKI-XRCC6-PPM1E-TTR-TUBA1A-SUCLG1-TRIAP1-AKT1S1-MYD88-NPPB-GDF11-INCENP-PLCB3-BECN1-PRKAB1-SOD1-TUBB1-NPHS2-NPHS1-EPS8L1-GDI1-TUBB2A-TUBB2B-SUCLG2-PEX3-TUBAL3-ERLIN1-MAGED1-GCH1-TUBB-CPS1-MEF2C-ZNF703-SLC22A6-CPLX1-EIF4EBP1-TUBE1-FLNA-CD19-STX1A-HDAC2-TOMM40L-HDAC6-SMAD6-SMAD7-TLE6-SMAD2-PARD6B-STXBP1-ACR-TRPC1-PARD6A-TRPC4-PANX1-DCTN1-SOX9-PXMP2-BCR-SET-MALT1-BHMT-RILP-TRADD-HIST1H3A-MAPK1-PVALB-NFKB1-NUFIP1-ACVR2B-TAL1-FOXP3-SSX2IP-GNB2-SLC27A5-GOPC-PAX2-CXADR-AIF1L-APBA1-MYL12A-LMO2-ID2-CCDC113-DDOST-SPP2-GATAD2B-PLN-ERCC8-BIRC8-ASF1A-CAB39-BIRC3-BIRC2-CTNNB1-CORO1A-PRELID1-HAND2-CHAF1B-SCAP-GNAT3-CDC20-SMARCA4-IQGAP1-YWHAZ-CEBPA-PRPS2-AXIN1-XRCC5-YWHAQ-UVRAG-SLC51B-RGS4-RGS6-HTT-YWHAB-APCS-CDCA8-RIPK1-MTA2-SIN3A-ANXA1-NOS1-SNTA1-TRAF6-KPNB1-VCL-VCP-PTRF-PRKCZ-SKIL-RAB3A-KRIT1-SSBP3-PRPSAP1-PPP1CC-TAB1-MYO6-ACTL7A-TUBG2-MBD2-COL6A1-COL6A2-BCL3)
Helps et al., Biochem J 2000, Lauderdale et al., Proc Natl Acad Sci U S A 2000, Didichenko et al., FEBS Lett 2000, Koh et al., Curr Biol 2002, Fan et al., Mol Cell Biol 2002, Groisman et al., Cell 2003, Offenhäuser et al., Mol Biol Cell 2004, Tagami et al., Cell 2004, Doyon et al., Mol Cell Biol 2004, Moore et al., Genomics 2004, Sun et al., Mol Cell 2004, Zang et al., J Cell Biochem 2004, Tian et al., Cancer Res 2005, An et al., Biochemistry 2005, Mahajan et al., Proc Natl Acad Sci U S A 2005, Vader et al., EMBO Rep 2006, Yeh et al., J Biol Chem 2006, Li et al., Immunol Rev 2006, Agbas et al., Biochem J 2007, Swiatecka-Urban et al., J Biol Chem 2007, McKeegan et al., Mol Cell Biol 2007, Shono et al., J Am Soc Nephrol 2007, Popov et al., Cell cycle (Georgetown, Tex.) 2007, Sato et al., J Biol Chem 2008, Fitzgerald et al., J Biol Chem 2008, Lyssand et al., J Biol Chem 2008, Figaro et al., FEBS Lett 2008, Ueda et al., Proc Natl Acad Sci U S A 2008, Shimojo et al., J Biol Chem 2008, Costantini et al., Blood 2009, Mitsuishi et al., J Biol Chem 2010, Masuda et al., J Biol Chem 2010, Koch et al., J Cell Sci 2010, Boëda et al., J Biol Chem 2011, Sircoulomb et al., EMBO Mol Med 2011, Hoxhaj et al., J Cell Sci 2012, Uckun et al., Proc Natl Acad Sci U S A 2012, Pusapati et al., J Biol Chem 2012, Ghai et al., Proc Natl Acad Sci U S A 2013, Kelly et al., PLoS Biol 2013, Chiang et al., PloS one 2013, Dauphinee et al., J Immunol 2013, Potting et al., Cell Metab 2013, Ludwig et al., PLoS Biol 2013, Lee et al., Proc Natl Acad Sci U S A 2013, Kobayashi et al., J Cell Biol 2014, Zheng et al., Am J Physiol 1994, Kumar et al., Biochem Biophys Res Commun 1998, Watabe-Uchida et al., J Cell Biol 1998, Haft et al., Mol Cell Biol 1998
Text-mined interactions from Literome
Nandan et al., Infect Immun 1999
:
Activation of phosphotyrosine phosphatase activity attenuates
mitogen activated protein kinase signaling and
inhibits c-FOS and
nitric oxide synthase expression in macrophages infected with Leishmania donovani
Xu et al., Life Sci 2000
(Glioma...) :
P38
MAPK , but not p42/p44 MAPK
mediated inducible
nitric oxide synthase expression in C6 glioma cells
Fabrizi et al., J Biol Chem 2001
:
The stimulation of inducible
nitric-oxide synthase by the prion protein fragment 106 -- 126 in human microglia is tumor necrosis factor-alpha dependent and
involves p38
mitogen activated protein kinase
Krainock et al., J Neurochem 2001
:
Regulation of functional
nitric oxide synthase-1 expression in cerebellar granule neurons by heregulin is post-transcriptional, and
involves mitogen activated protein kinase
Llansola et al., Brain Res 2002
:
Activation of N-methyl-D-aspartate ( NMDA ) receptors leads to increased phosphorylation of the microtubule associated protein MAP-2 by a mechanism that involves activation of
nitric oxide synthase and nitric oxide induced
activation of
mitogen activated protein kinase ( MAP-kinase )
Simkhovich et al., Cardiovasc Pathol 2003
(Myocardial Ischemia) :
Protective genes included
mitogen activated protein kinase activated protein kinase 3 ( MAPKAPK 3 ), heat shock proteins 70, 27, 22, B-crystalline, vascular endothelial growth factor, inducible
nitric oxide synthase and plasminogen activator inhibitors 1 and 2
Wang et al., J Pharmacol Exp Ther 2003
:
Up-regulation of endothelial
nitric-oxide synthase by endothelium derived hyperpolarizing factor
involves mitogen activated protein kinase and protein kinase C signaling pathways
Platten et al., Biochem Pharmacol 2003
:
Involvement of protein kinase Cdelta and
extracellular signal regulated kinase-2 in the suppression of microglial inducible
nitric oxide synthase expression by N- [ 3,4-dimethoxycinnamoyl ] -anthranilic acid ( tranilast )
Kitamura et al., Diabetologia 2003
:
Proinsulin C-peptide increases nitric oxide production by enhancing
mitogen activated protein-kinase dependent transcription of endothelial
nitric oxide synthase in aortic endothelial cells of Wistar rats
Anter et al., J Biol Chem 2004
:
Activation of endothelial
nitric-oxide synthase by the p38
MAPK in response to black tea polyphenols
Liu et al., Neurosci Lett 2006
:
It was shown that the selective inhibitor of
nNOS , 7-NINA ( 7-Nitroindazole, sodium salt ) ( 25 microg, i.t. )
attenuated not only the development of morphine antinociceptive tolerance, but also the activation of p38
MAPK in the spinal microglia induced by chronic intrathecal administration of morphine
Cullen et al., Atherosclerosis 2007
:
The inhibitory effect of resveratrol on 125I-MCP-1 binding to THP-1 cells and on CCR2 protein expression determined by FACS analysis was attenuated by treatment with L-NAME (
NOS inhibitor ), PD98059 (
MAPK inhibitor ) and LY294002 ( PI3K inhibitor ), whereas neither X/XO ( reactive oxygen species generator ) nor ICI182780 ( estrogen receptor antagonist ) had any effect
Grossini et al., Endocrinology 2008
:
In porcine aortic endothelial cells, genistein
induced the phosphorylation of endothelial
nitric oxide synthase and NO production through
ERK 1/2 , Akt, and p38 MAPK pathways, which was prevented by the concomitant treatment by butoxamine and fulvestrant
Johnson et al., Biol Reprod 2008
:
The protection offered by the caspase 2 inhibitor occurred upstream of mitochondria, involving suppression of
mitogen activated protein kinase ( MAPK) 14 activation and inducible
nitric oxide synthase ( NOS2 )
induction and, in turn, suppression of cytochrome c-mediated death pathway
Zhang et al., Cardiovasc Res 2009
:
The present study is designed to investigate the
role of
neuronal nitric oxide synthase (nNOS) in the regulation of vascular
mitogen activated protein kinase ( MAPK ) activity under basal and angiotensin II (Ang II) stimulated conditions
Tokudome et al., Arterioscler Thromb Vasc Biol 2009
(Ischemia) :
In cultured human endothelial cells, ANP treatment significantly stimulated mRNA expressions of vascular endothelial growth factor and endothelial
nitric oxide synthase via
Erk1/2 dependent mechanism
Ralay Ranaivo et al., Brain Res 2010
(MAP Kinase Signaling System) :
Albumin activated ERK1/2, p38
MAPK and JNK signaling pathways in astrocytes, and
induced the production of interleukin (IL)-1beta, inducible
nitric oxide (NO) synthase , the NO metabolite nitrite, and the chemokine CX3CL1 while reducing the level of S100B
Cheng et al., Br J Pharmacol 2012
(Hypotension) :
Effects of a selective antagonist of Y ( 1 ) receptors, a PKC inhibitor, a PI3 kinase inhibitor, a
NOS inhibitor, an endothelial NOS (eNOS)-selective inhibitor, a neuronal NOS (nNOS)-specific inhibitor or a
MAPK inhibitor , on responses to microinjection of NPY into the NTS of Wistar-Kyoto rats were studied to determine the underlying mechanisms
Chrestensen et al., FEBS open bio 2012
:
These observations strongly suggest a direct
role for
MAPK in regulation of
NOS with implications for signaling pathways including angiogenesis and control of vascular tone
Nishiya et al., FEBS Lett 1997
(Glioma) :
Activation of Stat1 and subsequent transcription of inducible
nitric oxide synthase gene in C6 glioma cells is
independent of interferon-gamma induced
MAPK activation that is mediated by p21ras