◀ Back to MAPK3
MAP3K7 — MAPK3
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Goswami et al., Dev Biol 2001
(MAP Kinase Signaling System) :
Overexpression of
TAK1 led to a reduction in
MAPK activity in early gastrula ectoderm
McDermott et al., J Biol Chem 2002
:
In addition we found a
role for
TAK-1 in the activation of p38
MAPK by IL-1, with TAK-1 also associating with active Ras
Kettner-Buhrow et al., Biochem Biophys Res Commun 2006
(MAP Kinase Signaling System) :
dsiRNA against TAK1 or TAB1 significantly suppressed their target proteins as well as
TAK1 mediated activation of NFkappaB, p38
MAPK , and JNK, and of IL-8 transcription
Kim et al., American journal of physiology. Renal physiology 2007
:
TGF-beta activated kinase 1 and TAK1 binding protein 1 cooperate to
mediate TGF-beta1 induced MKK3-p38
MAPK activation and stimulation of type I collagen ... Transient overexpression of
TAK1 with TAB1
enhanced the activation of MKK3 and p38
MAPK with or without TGF-beta(1) stimulation, whereas a dominant negative mutant of TAK1 ( TAK1DN ) suppressed TGF-beta(1) induced activation of MKK3 and p38 MAPK
Windheim et al., Biochem J 2007
:
We also show that RIP2
induces the activation of the protein kinase
TAK1 ( transforming-growth-factor-beta activated kinase-1 ), that a dominant negative mutant of TAK1 inhibits RIP2 induced activation of JNK ( c-Jun N-terminal kinase ) and p38alpha
MAPK , and that signalling downstream of NOD2 or RIP2 is reduced by the TAK1 inhibitor ( 5Z ) -7-oxozeaenol or in TAK1-deficient cells
Adhikari et al., Oncogene 2007
:
Stimulation of cells with cytokines and microbial pathogens results in the activation of
TAK1 , which subsequently
activates the I-kappa B kinase complex (IKK) and
mitogen activated protein ( MAP ) kinases , culminating in the activation of NF-kappaB and AP-1, respectively
Kodym et al., RNA 2008
(MAP Kinase Signaling System) :
Activation of
TAK1-D leads to the downstream activation of the p38
MAPK and of SAPK/JNK but not the NFkappaB pathway
Kumar et al., J Immunol 2009
(Inflammation) :
In this study, we tested the hypothesis that
TAK1 ( TGF-beta activated kinase 1 ) is
involved in TWEAK induced activation of NF-kappaB and
MAPK and expression of proinflammatory protein
Mikkelsen et al., J Biol Chem 2009
:
We also observed that TRAF2 and
TAK1 were
essential for RIG-I mediated activation of p38
MAPK
Korchnak et al., Cell Signal 2009
:
Mixed lineage kinase 3 (MLK3) is a mitogen activated protein kinase kinase kinase (
MAP3K ) that
activates multiple mitogen activated protein kinase (
MAPK ) pathways in response to growth factors, stresses and the pro-inflammatory cytokine, tumor necrosis factor (TNF)
Cheng et al., J Biomed Mater Res A 2010
(Inflammation...) :
The critical
role for
TAK1 in
p38MAPK and NFkappaB activation was as well confirmed by the inhibition of p38MAPK and NFkappaB activity following 5Z-7-oxozeaenol, a selective inhibitor of TAK1
Qian et al., J Immunol 2011
(Parkinson Disease) :
Salmeterol significantly inhibited LPS induced production of microglial proinflammatory neurotoxic mediators, such as TNF-a, superoxide, and NO, as well as the inhibition of
TAK1 mediated phosphorylation of
MAPK and p65 NF-?B
Pera et al., Am J Physiol Lung Cell Mol Physiol 2011
(Airway Remodeling...) :
PDGF induced DNA synthesis and
extracellular signal regulated kinase-1/2 phosphorylation in BTSM cells were strongly
inhibited by both LL-Z-1640-2 pretreatment and transfection of dominant negative
TAK1
Avila et al., Innate Immun 2012
:
Lyn kinase controls TLR4 dependent IKK and
MAPK activation
modulating the activity of
TRAF-6/TAK-1 protein complex in mast cells
Tran et al., J Biol Chem 2012
(MAP Kinase Signaling System) :
In agreement with this, overexpression of ASK1 or
TAK1 resulted in enhanced
p38MAPK activation, and their knockdown inhibited p38MAPK in C2C12 cells ... Overexpression of
TAK1 or ASK1 in Cdo ( -/- ) myoblasts and Cdo depleted C2C12 cells
restored p38MAPK activation as well as myotube formation
Pera et al., Am J Physiol Lung Cell Mol Physiol 2012
(MAP Kinase Signaling System) :
Similarly, expression of dominant negative
TAK1 inhibited CSE induced
ERK-1/2 phosphorylation ... These data indicate that
TAK1 plays a major role in CSE induced
ERK-1/2 and NF-?B signaling and in IL-8 release by human ASM cells
López-Pelaéz et al., Mol Biol Cell 2012
(Inflammation...) :
Cot/tpl2 is the only
MAP3K that
activates MKK1/2-Erk1/2 in Toll-like receptor activated macrophages
Yumoto et al., J Biol Chem 2013
(Cleft Palate) :
Our studies show that in neural crest derived craniofacial ecto-mesenchymal cells,
Tak1 is not only
required for TGF-ß- and bone morphogenetic protein induced p38
Mapk activation but also plays a role in agonist induced C-terminal and linker region phosphorylation of the receptor mediated R-Smads
Hirata et al., J Immunol 2013
:
TAK1 , a member of MAPK kinase kinase ( MAPKK-K ) family, can
activate JNK, p38
MAPK , and NF-?B signaling pathways