Gene interactions and pathways from curated databases and text-mining

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CHUK — MAP3K3

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Zhao et al., J Biol Chem 1999 : The essential features of this cascade are that a mitogen activated protein kinase kinase kinase ( MAP3K ) activates an IkappaB kinase (IKK) that site-specifically phosphorylates IkappaB ... We now show that MEKK2 and MEKK3 can in vivo activate IKK-alpha and IKK-beta, induce site-specific IkappaBalpha phosphorylation, and, relatively modestly, activate an NF-kappaB reporter gene
Yang et al., Nat Immunol 2001 : We have shown that MEKK3 is required for IKK activation and functions downstream of receptor interacting protein ( RIP ) and TNF receptor- associated factor 2
Sun et al., Cell Signal 2009 : Together, our results provide the genetic evidence that MEKK3 but not TAK1 is required for LPA receptor mediated IKK-NF-kappaB activation