Gene interactions and pathways from curated databases and text-mining

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AKT1 — MAP3K11

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Barthwal et al., J Biol Chem 2003 : Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival ... Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival
Kraus et al., Cancer Res 2004 (MAP Kinase Signaling System...) : The reduction of PKB activity releases PKB induced inhibition of MLK3 and thus further stimulates JNK activity and accelerates the apoptotic effect of GnRH-a
Yin et al., J Neurochem 2005 (Brain Ischemia...) : The above mentioned results lead us to conclude that, in the hippocampal CA1 region, preconditioning inhibits MLK3 activation after lethal ischaemia and reperfusion and, furthermore, this effect is mediated by Akt1 activation through NMDA receptor stimulation
Zhang et al., J Neurochem 2006 (Brain Ischemia...) : Akt inhibits MLK3/JNK3 signaling by inactivating Rac1 : a protective mechanism against ischemic brain injury