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AKT1 — MAP3K11
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
AKT1
—
MAP3K11
(physical association, affinity chromatography technology)
Barthwal et al., J Biol Chem 2003*
-
IRef Biogrid Interaction:
AKT1
—
MAP3K11
(direct interaction, pull down)
Barthwal et al., J Biol Chem 2003*
-
IRef Hprd Interaction:
AKT1
—
MAP3K11
(in vitro)
Barthwal et al., J Biol Chem 2003*
-
IRef Hprd Interaction:
AKT1
—
MAP3K11
(in vivo)
Barthwal et al., J Biol Chem 2003*
-
IRef Innatedb Interaction:
AKT1
—
MAP3K11
(unknown, -)
Barthwal et al., J Biol Chem 2003*
-
IRef Ophid Interaction:
AKT1
—
MAP3K11
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Barthwal et al., J Biol Chem 2003
:
Negative
regulation of
mixed lineage kinase 3 by
protein kinase B/AKT leads to cell survival ... Negative
regulation of
mixed lineage kinase 3 by protein kinase
B/AKT leads to cell survival
Kraus et al., Cancer Res 2004
(MAP Kinase Signaling System...) :
The reduction of PKB activity releases
PKB induced inhibition of
MLK3 and thus further stimulates JNK activity and accelerates the apoptotic effect of GnRH-a
Yin et al., J Neurochem 2005
(Brain Ischemia...) :
The above mentioned results lead us to conclude that, in the hippocampal CA1 region, preconditioning inhibits
MLK3 activation after lethal ischaemia and reperfusion and, furthermore, this effect is
mediated by
Akt1 activation through NMDA receptor stimulation
Zhang et al., J Neurochem 2006
(Brain Ischemia...) :
Akt inhibits
MLK3/JNK3 signaling by inactivating Rac1 : a protective mechanism against ischemic brain injury