Gene interactions and pathways from curated databases and text-mining

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MAP3K1 — MAPK3

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: MAPK3 → MAP3K1 (increases, MAP3K1 Activity, MAPK3 Activity)
    Evidence: Expression of MEKK1-KM attenuated activation of ERK and JNK (Figures 6A and 6B). Selective activation of MEKK1 was sufficient for the activation of both MAP kinases.

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Uhlik et al., Biochem Cell Biol 2004 (MAP Kinase Signaling System) : Wiring diagrams of MAPK regulation by MEKK1 , 2, and 3
Korchnak et al., Cell Signal 2009 : Mixed lineage kinase 3 (MLK3) is a mitogen activated protein kinase kinase kinase ( MAP3K ) that activates multiple mitogen activated protein kinase ( MAPK ) pathways in response to growth factors, stresses and the pro-inflammatory cytokine, tumor necrosis factor (TNF)
López-Pelaéz et al., Mol Biol Cell 2012 (Inflammation...) : Cot/tpl2 is the only MAP3K that activates MKK1/2-Erk1/2 in Toll-like receptor activated macrophages
Xu et al., Proc Natl Acad Sci U S A 1995 : MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen activated protein kinase