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MAP2K6 — MAPK6
Pathways - manually collected, often from reviews:
-
WikiPathways ESC Pluripotency Pathways:
MAP2K1/MAP2K3/SEPP1/MAP2K5/MAP2K6/MAP2K2
→
MAPK7/MAPK1/MAPK6/MAPK4/MAPK12
(activation)
-
WikiPathways Focal Adhesion:
SEPP1/MAP2K5/MAP2K6/MAP2K2/MAP2K3/MAP2K1
→
MAPK4/MAPK7/MAPK12/MAPK1/MAPK6
(activation)
Text-mined interactions from Literome
Martel-Pelletier et al., Arthritis Rheum 1999
(Osteoarthritis) :
Within minutes, IL-17 induced the phosphorylation of
mitogen activated protein kinase kinase-1/2 ( MEK-1/2 ), -3/6 ( MKK-3/6 ), p44/42, p38, and inhibitor of nuclear factor kappaB ( I kappaB)-alpha, as well as the
activation of
mitogen activated protein kinase activated protein kinase-1 and -2 ( MAPKAPK-1 and -2 )
Tu et al., J Biomed Sci 2001
(Carcinoma, Hepatocellular) :
On the other hand, PD98059, a specific inhibitor of
mitogen activated protein kinase kinase ,
blocks TPA induced
MAPK activation but has no effect on TPA induced tyrosine phosphorylation
Huang et al., Biochem Biophys Res Commun 2003
:
MAP3Ks are components of a three tiered protein kinase pathway in which a MAP3K phosphorylates and activates a
mitogen activated protein kinase kinase ( MAP2K ), which in turn
activates a
mitogen activated protein kinase ( MAPK )
Wu et al., Free Radic Biol Med 2010
(Drug-Induced Liver Injury) :
This was followed by
activation of
MKK3/MKK6 and MKK4/MKK7 at 4-8 or 12h and then JNK/p38
MAPK at 8 to 12h
Lee et al., Nat Med 2011
(Obesity) :
Further, we show that
activation of p38
MAPK by expression of constitutively active
MAP kinase kinase 6 ( MKK6Glu ) greatly enhances nuclear translocation of Xbp1s, reduces endoplasmic reticulum stress and establishes euglycemia in severely obese and diabetic mice
Huwiler et al., Br J Pharmacol 1994
:
2. Both nucleotides stimulate phosphorylation and
activation of
mitogen activated protein kinase and a biphasic phosphorylation of the up-stream
mitogen activated protein kinase kinase
Daum et al., FEBS Lett 1998
:
Pervanadate inhibits
mitogen activated protein kinase kinase-1 in a
p38MAPK dependent manner