Gene interactions and pathways from curated databases and text-mining

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MAP2K6 — MAPK6

Pathways - manually collected, often from reviews:

  • WikiPathways ESC Pluripotency Pathways: MAP2K1/MAP2K3/SEPP1/MAP2K5/MAP2K6/MAP2K2 → MAPK7/MAPK1/MAPK6/MAPK4/MAPK12 (activation)
  • WikiPathways Focal Adhesion: SEPP1/MAP2K5/MAP2K6/MAP2K2/MAP2K3/MAP2K1 → MAPK4/MAPK7/MAPK12/MAPK1/MAPK6 (activation)

Text-mined interactions from Literome

Martel-Pelletier et al., Arthritis Rheum 1999 (Osteoarthritis) : Within minutes, IL-17 induced the phosphorylation of mitogen activated protein kinase kinase-1/2 ( MEK-1/2 ), -3/6 ( MKK-3/6 ), p44/42, p38, and inhibitor of nuclear factor kappaB ( I kappaB)-alpha, as well as the activation of mitogen activated protein kinase activated protein kinase-1 and -2 ( MAPKAPK-1 and -2 )
Tu et al., J Biomed Sci 2001 (Carcinoma, Hepatocellular) : On the other hand, PD98059, a specific inhibitor of mitogen activated protein kinase kinase , blocks TPA induced MAPK activation but has no effect on TPA induced tyrosine phosphorylation
Huang et al., Biochem Biophys Res Commun 2003 : MAP3Ks are components of a three tiered protein kinase pathway in which a MAP3K phosphorylates and activates a mitogen activated protein kinase kinase ( MAP2K ), which in turn activates a mitogen activated protein kinase ( MAPK )
Wu et al., Free Radic Biol Med 2010 (Drug-Induced Liver Injury) : This was followed by activation of MKK3/MKK6 and MKK4/MKK7 at 4-8 or 12h and then JNK/p38 MAPK at 8 to 12h
Lee et al., Nat Med 2011 (Obesity) : Further, we show that activation of p38 MAPK by expression of constitutively active MAP kinase kinase 6 ( MKK6Glu ) greatly enhances nuclear translocation of Xbp1s, reduces endoplasmic reticulum stress and establishes euglycemia in severely obese and diabetic mice
Huwiler et al., Br J Pharmacol 1994 : 2. Both nucleotides stimulate phosphorylation and activation of mitogen activated protein kinase and a biphasic phosphorylation of the up-stream mitogen activated protein kinase kinase
Daum et al., FEBS Lett 1998 : Pervanadate inhibits mitogen activated protein kinase kinase-1 in a p38MAPK dependent manner