Gene interactions and pathways from curated databases and text-mining

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HIF1A — MAP2K5

Text-mined interactions from Literome

Luwor et al., Oncogene 2005 : Pharmacologic inhibition of phosphatidylinositol 3-kinase with LY294002 reduced the HIF-1alpha level in both normoxic and hypoxic A431 cells, whereas inhibition of the mitogen activated protein kinase kinase by PD98059 reduced the level of HIF-1alpha only in normoxic A431 cells
Pi et al., Circ Res 2005 : BMK1 activation by constitutively active ( CA ) -MEK5 inhibited HIF1alpha activity by 46+/-4 %, suggesting BMK1 functions as a negative regulator of HIF1alpha activation