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AKT1 — MAP2K4

Pathways - manually collected, often from reviews:

• KEGG MAPK signaling pathway: AKT1/AKT2/AKT3 → MAP2K4 (protein-protein, inhibition)
• WikiPathways MAPK Signaling Pathway: AKT1/AKT2/AKT3 → MAP2K4 (mim-inhibition)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MAP2K4 — AKT1 (physical association, affinity chromatography technology) Song et al., J Cell Biol 2005*
• IRef Biogrid Interaction: MAP2K4 — AKT1 (direct interaction, enzymatic study) Park et al., J Biol Chem 2002*
• IRef Biogrid Interaction: MAP2K4 — AKT1 (physical association, affinity chromatography technology) Park et al., J Biol Chem 2002*
• IRef Hprd Interaction: MAP2K4 — AKT1 (in vitro) Park et al., J Biol Chem 2002*
• IRef Hprd Interaction: MAP2K4 — AKT1 (in vivo) Park et al., J Biol Chem 2002*
• IRef Innatedb Interaction: MAP2K4 — AKT1 (unknown, -) Song et al., J Cell Biol 2005*
• IRef Ophid Interaction: MAP2K4 — AKT1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: MAP2K4 — AKT1 (aggregation, confirmational text mining) Park et al., J Biol Chem 2002*

Text-mined interactions from Literome

Park et al., J Biol Chem 2002 : Akt ( protein kinase B ) negatively regulates SEK1 by means of protein phosphorylation ... Expression of a constitutively active form of Akt also inhibited both SEK1 and JNK1 activation, but not that of MEKK1, in transfected 293T cells
Baudhuin et al., Mol Pharmacol 2002 : Akt activation induced by lysophosphatidic acid and sphingosine-1-phosphate requires both mitogen activated protein kinase kinase and p38 mitogen activated protein kinase and is cell-line specific
Dai et al., Blood 2005 (Acute Disease...) : Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK
Song et al., J Cell Biol 2005 (MAP Kinase Signaling System) : Concomitantly, Akt1 interacts with stress activated protein kinase/extracellular signal regulated kinase (SEK) 1 ( also known as MKK4 ) and inhibits SEK1 activity
Imarisio et al., Clin Sci (Lond) 2012 (Fatty Liver) : CGS21680 action required PI3K ( phosphoinositide 3-kinase ) /Akt mediated block of MKK4/SEK1