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MAP2K2 — MAPK14
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Martel-Pelletier et al., Arthritis Rheum 1999
(Osteoarthritis) :
Within minutes, IL-17 induced the phosphorylation of
mitogen activated protein kinase kinase-1/2 ( MEK-1/2 ), -3/6 ( MKK-3/6 ), p44/42, p38, and inhibitor of nuclear factor kappaB ( I kappaB)-alpha, as well as the
activation of
mitogen activated protein kinase activated protein kinase-1 and -2 ( MAPKAPK-1 and -2 ) ... Within minutes, IL-17 induced the phosphorylation of mitogen activated protein kinase kinase-1/2 (
MEK-1/2 ), -3/6 ( MKK-3/6 ), p44/42, p38, and inhibitor of nuclear factor kappaB ( I kappaB)-alpha, as well as the
activation of
mitogen activated protein kinase activated protein kinase-1 and -2 ( MAPKAPK-1 and -2 )
Newton et al., Br J Pharmacol 2000
:
We have therefore used these cells to examine the effect of the selective
mitogen activated protein ( MAP ) kinase inhibitors ; PD098059, a mitogen activated and extracellular regulated kinase kinase ( MEK) 1 inhibitor, UO126, a dual MEK1 &
MEK2 inhibitor , and SB203580, a p38 MAP kinase inhibitor in the IL-1beta dependent release of PGE ( 2 )
Tu et al., J Biomed Sci 2001
(Carcinoma, Hepatocellular) :
On the other hand, PD98059, a specific inhibitor of
mitogen activated protein kinase kinase ,
blocks TPA induced
MAPK activation but has no effect on TPA induced tyrosine phosphorylation
Huang et al., Biochem Biophys Res Commun 2003
:
MAP3Ks are components of a three tiered protein kinase pathway in which a MAP3K phosphorylates and activates a
mitogen activated protein kinase kinase ( MAP2K ), which in turn
activates a
mitogen activated protein kinase ( MAPK )
Aroor et al., Alcohol 2009
:
These results suggest that Ang II-mediated accumulation of phospho-p42/44
MAPK in the hepatocyte nucleus
involves MEK 1/2 dependent activation and this effect is potentiated by ethanol
Huwiler et al., Br J Pharmacol 1994
:
2. Both nucleotides stimulate phosphorylation and
activation of
mitogen activated protein kinase and a biphasic phosphorylation of the up-stream
mitogen activated protein kinase kinase
Bazan et al., Curr Eye Res 1997
:
Corneal tissue expresses ERK2 or MAPK, and both MEK1 and
MEK2 , the immediate upstream
regulators of
MAPK
Daum et al., FEBS Lett 1998
:
Pervanadate inhibits
mitogen activated protein kinase kinase-1 in a
p38MAPK dependent manner
Tsatsanis et al., Oncogene 1998
(Lymphoma, T-Cell) :
Since the activation of NFAT is MAPK dependent these findings suggested that the activation of
MAPK by Tpl-2 is either independent or only partially
dependent on MEK1 and
MEK2