Gene interactions and pathways from curated databases and text-mining

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MAP2K1 — MAP3K5

Text-mined interactions from Literome

Tu et al., Cell Signal 2003 : They consist of a three-kinase module in which a mitogen activated protein kinase kinase kinase ( MAP3K ) activates a mitogen activated protein kinase kinase ( MAP2K ), which in turn activates MAPK
Huang et al., Biochem Biophys Res Commun 2003 : MAP3Ks are components of a three tiered protein kinase pathway in which a MAP3K phosphorylates and activates a mitogen activated protein kinase kinase ( MAP2K ), which in turn activates a mitogen activated protein kinase ( MAPK )
Yamaguchi et al., J Clin Invest 2004 (MAP Kinase Signaling System) : The expression level and activation of MEK1/2 or ERK showed no difference, but the kinase activity of apoptosis signal regulating kinase 1 ( ASK1 ), JNK, or p38 increased significantly compared with that in controls
López-Pelaéz et al., Mol Biol Cell 2012 (Inflammation...) : Cot/tpl2 is the only MAP3K that activates MKK1/2-Erk1/2 in Toll-like receptor activated macrophages