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AKT1 — MAP2K1
Text-mined interactions from Literome
Baudhuin et al., Mol Pharmacol 2002
:
Akt activation induced by lysophosphatidic acid and sphingosine-1-phosphate
requires both
mitogen activated protein kinase kinase and p38 mitogen activated protein kinase and is cell-line specific
Chien et al., J Lipid Res 2003
:
Overexpression of p85-DN or
Akt-DN mutants
attenuated MEK1/2 and p42/p44 MAPK phosphorylation stimulated by OxLDL and EGF
Sinha et al., J Biol Chem 2004
:
Pharmacological inhibition of
MEK1/2 , the immediate upstream kinase for ERK1/2, not only
prevented the decrease in phosphorylated
Akt , but also prolonged MK-PT cell survival
Taniguchi et al., Mol Reprod Dev 2004
(MAP Kinase Signaling System) :
Here, we showed that HGF activated the distinct phosphorylation of Raf-1,
MEK1/2 , and ERK1/2, but did not
induce phosphorylation of
Akt
Hattrup et al., Breast Cancer Res 2006
(Breast Neoplasms...) :
Additional changes were seen at the protein level, such as increased expression of c-Myc, heightened phosphorylation of
AKT , and decreased
activation of
MEK1/2 and ERK1/2
Menges et al., Oncogene 2008
(MAP Kinase Signaling System) :
Constitutive activation of Raf or
methyl ethyl ketone 1 (MEK1) leads to inhibition of
AKT and cellular arrest
Kim et al., Exp Mol Med 2009
:
A chemical inhibitor of
MEK1/2 or PI3K
reduced phosphorylation of ERK or
Akt , respectively, and also inhibited CSE mediated MMP-9 induction
Ko et al., Mol Cancer Res 2009
(Carcinoma, Non-Small-Cell Lung...) :
Blocking the
activations of ERK1/2 and
AKT by
MKK1/2 inhibitor ( U0126 ) and phosphoinositide 3-kinase inhibitor ( wortmannin ) suppressed the expression of Rad51 and enhanced the erlotinib induced cell death in erlotinib-resistant cells
Lasala et al., Am J Physiol Endocrinol Metab 2011
:
Blocking PKA abolished the effect of cAMP on Sox9, Sf1, and Gata4 expression, inhibiting
PI3K/PKB impaired the effect on Sf1 and Gata4, and
reducing MEK1/2 and p38 MAPK activities curtailed Gata4 increase
Zmajkovicova et al., Mol Cell 2013
(Autoimmune Diseases...) :
MEK1 Is
Required for PTEN Membrane Recruitment,
AKT Regulation, and the Maintenance of Peripheral Tolerance