Gene interactions and pathways from curated databases and text-mining

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AKT1 — MAP2K1

Text-mined interactions from Literome

Baudhuin et al., Mol Pharmacol 2002 : Akt activation induced by lysophosphatidic acid and sphingosine-1-phosphate requires both mitogen activated protein kinase kinase and p38 mitogen activated protein kinase and is cell-line specific
Chien et al., J Lipid Res 2003 : Overexpression of p85-DN or Akt-DN mutants attenuated MEK1/2 and p42/p44 MAPK phosphorylation stimulated by OxLDL and EGF
Sinha et al., J Biol Chem 2004 : Pharmacological inhibition of MEK1/2 , the immediate upstream kinase for ERK1/2, not only prevented the decrease in phosphorylated Akt , but also prolonged MK-PT cell survival
Taniguchi et al., Mol Reprod Dev 2004 (MAP Kinase Signaling System) : Here, we showed that HGF activated the distinct phosphorylation of Raf-1, MEK1/2 , and ERK1/2, but did not induce phosphorylation of Akt
Hattrup et al., Breast Cancer Res 2006 (Breast Neoplasms...) : Additional changes were seen at the protein level, such as increased expression of c-Myc, heightened phosphorylation of AKT , and decreased activation of MEK1/2 and ERK1/2
Menges et al., Oncogene 2008 (MAP Kinase Signaling System) : Constitutive activation of Raf or methyl ethyl ketone 1 (MEK1) leads to inhibition of AKT and cellular arrest
Kim et al., Exp Mol Med 2009 : A chemical inhibitor of MEK1/2 or PI3K reduced phosphorylation of ERK or Akt , respectively, and also inhibited CSE mediated MMP-9 induction
Ko et al., Mol Cancer Res 2009 (Carcinoma, Non-Small-Cell Lung...) : Blocking the activations of ERK1/2 and AKT by MKK1/2 inhibitor ( U0126 ) and phosphoinositide 3-kinase inhibitor ( wortmannin ) suppressed the expression of Rad51 and enhanced the erlotinib induced cell death in erlotinib-resistant cells
Lasala et al., Am J Physiol Endocrinol Metab 2011 : Blocking PKA abolished the effect of cAMP on Sox9, Sf1, and Gata4 expression, inhibiting PI3K/PKB impaired the effect on Sf1 and Gata4, and reducing MEK1/2 and p38 MAPK activities curtailed Gata4 increase
Zmajkovicova et al., Mol Cell 2013 (Autoimmune Diseases...) : MEK1 Is Required for PTEN Membrane Recruitment, AKT Regulation, and the Maintenance of Peripheral Tolerance