Gene interactions and pathways from curated databases and text-mining

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MAFB — MAPK3

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: MAFB → MAPK3 (increases, MAFB Activity) Sevinsky et al., Mol Cell Biol 2004*
    Evidence: MafB/Kreisler is induced in response to ERK and synergizes with GATA and Ets to enhance transcription from the proximal promoter. The requirement for MafB in promoter regulation is demonstrated by inhibition of transactivation following dominant-negative or antisense suppression of MafB function. Thus, ERK promotes megakaryocyte differentiation by coordinate regulation of nuclear factors that synergize in GPIIb promoter regulation. These results establish a novel role for MafB as a regulator of ...