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MAFA — MAPK6

Text-mined interactions from Literome

Kondo et al., Mol Endocrinol 2009 (Hyperglycemia) : We demonstrate that MafA protein stability in MIN6 cells and isolated mouse islets is regulated by both p38 MAPK and glycogen synthase kinase 3
El Khattabi et al., Mol Endocrinol 2013 : We show that under oxidative and nonoxidative conditions p38 MAPK directly binds to MafA and triggers MafA degradation via ubiquitin proteasomal pathway ... These results identify two distinct pathways mediating p38 MAPK dependent MafA degradation under oxidative and nonoxidative conditions and show that inhibiting MafA degradation under oxidative stress ameliorates ß-cell dysfunction and could lead to novel therapies for diabetes