Gene interactions and pathways from curated databases and text-mining

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LYN — MAPK3

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Kawauchi et al., Int J Hematol 2002 (Leukemia, Lymphocytic, Chronic, B-Cell...) : In B-CLL cells, BCR cross linking neither induced activation nor enhanced the activities of Lyn , Syk, p21ras, JNK, p38 MAPK, or Akt kinases, whereas p38 MAPK and Akt were constitutively active
Tomkowicz et al., Blood 2006 (Acquired Immunodeficiency Syndrome...) : Stimulation of human monocyte derived macrophages with either HIV-1 gp120 or MIP-1beta results in the CCR5 mediated activation of Lyn and the concomitant Lyn dependent activation of the mitogen activated protein ( MAP ) kinase ERK-1/2
Jiang et al., J Exp Med 1998 : However, BCR mediated p38 MAPK activation was abolished in Lyn/Syk double deficient cells, demonstrating that either Lyn or Syk alone may be sufficient to activate p38 MAPK
Hayashi et al., Nature 1999 : As a result of activation of Lyn , the mitogen activated protein kinase ( MAPK ) signalling pathway is activated, and the expression of brain derived neurotrophic factor (BDNF) messenger RNA is increased in a Lyn-kinase dependent manner