Gene interactions and pathways from curated databases and text-mining

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EPO — LYN

Pathways - manually collected, often from reviews:

  • NCI Pathway Database EPO signaling pathway: EPO/EPOR (dimer) complex (EPO-EPOR) → LYN (LYN) (modification, collaborate)
  • NCI Pathway Database EPO signaling pathway: EPO/EPOR (dimer) complex (EPO-EPOR) → EPO/EPOR (dimer)/LYN complex (EPO-EPOR-LYN) (modification, collaborate)
  • NCI Pathway Database EPO signaling pathway: LYN (LYN) → EPO/EPOR (dimer)/LYN complex (EPO-EPOR-LYN) (modification, collaborate)
  • NCI Pathway Database EPO signaling pathway: EPO/EPOR (dimer)/JAK2 complex (EPO-EPOR-JAK2) → EPO/EPOR (dimer)/LYN complex (EPO-EPOR-LYN) (modification, activates)
    Penta et al., J Biol Chem 1995
    Evidence: assay, other species
  • NCI Pathway Database EPO signaling pathway: EPO/EPOR (dimer)/JAK2 complex (EPO-EPOR-JAK2) → EPO/EPOR (dimer)/LYN complex (EPO-EPOR-LYN) (modification, activates)
    Ren et al., J Biol Chem 1994*
    Evidence: assay
  • NCI Pathway Database EPO signaling pathway: EPO/EPOR (dimer)/LYN complex (EPO-EPOR-LYN) → p38 alpha (MAPK14) (modification, activates)
  • NCI Pathway Database EPO signaling pathway: EPO/EPOR (dimer)/JAK2 complex (EPO-EPOR-JAK2) → EPO/EPOR (dimer)/LYN complex (EPO-EPOR-LYN) (modification, activates)
    Penta et al., J Biol Chem 1995
    Evidence: assay, other species

Text-mined interactions from Literome

Tilbrook et al., Cancer Res 2001 (Cell Transformation, Neoplastic...) : In normal erythroid progenitors, erythropoietin enhanced phosphorylation of Lyn ; moreover, exogenous Lyn increased colony forming unit-erythroid, but not burst forming uniterythroid, colonies from normal progenitors, demonstrating a stage-specific effect of the kinase
Boudot et al., Biochem Biophys Res Commun 2003 : Moreover Epo activated Lyn phosphorylates in vitro PLC-gamma 2 immunoprecipitated from unstimulated cells
Kosmider et al., PloS one 2009 (Leukemia) : Furthermore, enforced expression of Lyn in the cell lines increased cell proliferation in response to Epo , but reduced cell growth in response to SCF in accordance with Lyn ability to down-regulate Kit expression
Slavova-Azmanova et al., Blood 2013 (Anemia, Hemolytic) : Gain-of-function Lyn induces anemia : appropriate Lyn activity is essential for normal erythropoiesis and Epo receptor signaling