Gene interactions and pathways from curated databases and text-mining

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LTA — TLR4

Text-mined interactions from Literome

Yang et al., Infect Immun 2001 : These findings suggested that LTA as well as LPS activated human monocytic cells in a CD14- and TLR4 dependent manner, whereas MDP exhibited activity in a CD14-, TLR4-, and probably TLR2 independent manner and exhibited synergistic and priming effects on the cells for cytokine production in response to various bacterial components
Møller et al., Cytokine 2005 : E. coli-LPS and LTA induced a dose dependent increase of CD14, TLR2 and TLR4 expression on monocytes in whole blood
Zorko et al., J Antimicrob Chemother 2008 : Both compounds prevent cell activation of TLR4 and TLR2 by LPS and LTA , respectively
Nerren et al., Vet Immunol Immunopathol 2010 (Poultry Diseases) : The aim of the present study was to gain better insight into the nature of the ligand for TLR15 by characterizing gene expression patterns of TLR15 by heterophils in response to numerous bacterial derived TLR agonists LPS, flagellin, CpG oligodeoxynucleotides, lipotechoic acid (LTA) , peptidoglycan ( PGN ), and Pam3CSK4 (PAM), stimulation with live Salmonella enterica serovar Enteritidis ( SE-used as a positive control ), chicken isolates of Escherichia coli ( EC ) and Enterococcus gallinarum ( EG ), the equine-specific pathogen Rhodococcus equi, and stimulation with heat killed, and formalin killed SE, EC, and EG
Fargues et al., Bull Group Int Rech Sci Stomatol Odontol 2010 : We provide here additional data showing the fine localization of NOD2 in healthy dental pulps, as well as differential regulation of TLR2, TLR4 , NOD2, CCL2 and CXCL8 genes by LTA and the synthetic TLR2 agonists Pam2CSK4 and Pam3CSK4