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IL12A — LTA

Text-mined interactions from Literome

Hermann et al., Eur J Immunol 2002 : While the maximal achievable monokine release in response to LTA was comparable to LPS, all LTA induced significantly less IL-12 and IFN-gamma ... In conclusion, LTA compared to LPS, are weak inducers of IL-12 and subsequent IFN-gamma formation which might explain their lower toxicity in vivo
Dalpke et al., Immunobiology 2002 : In contrast, LTA suppressed IL12p40 secretion induced by CpG-DNA in RAW cells and peritoneal macrophages but not in dendritic cells
Mohamadzadeh et al., Proc Natl Acad Sci U S A 2011 (Colitis) : The data show that the L. acidophilus LTA negative in LTA ( NCK2025 ) not only down-regulated IL-12 and TNFa but also significantly enhanced IL-10 in DCs and controlled the regulation of costimulatory DC functions, resulting in their inability to induce CD4 ( + ) T-cell activation
Cleveland et al., Infect Immun 1996 : In contrast, lipoteichoic acid (LTA) , a predominant surface glycolipid of gram positive bacteria, potently induced IL-12 p40 gene expression ... A competitive LPS antagonist, Rhodobacter sphaeroides LPS, inhibited LTA induced IL-12 production, suggesting a common pathway for LPS and LTA in IL-12 activation