Gene interactions and pathways from curated databases and text-mining

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LRRK2 — TLR4

Text-mined interactions from Literome

Moehle et al., J Neurosci 2012 (Inflammation) : LRRK2 inhibition blocks TLR4 stimulated microglial process outgrowth and impairs ADP stimulated microglial chemotaxis
Dzamko et al., PloS one 2012 (Parkinson Disease) : Here we demonstrate that stimulation of the Toll-Like Receptor ( TLR ) pathway by MyD88 dependent agonists in bone marrow derived macrophages ( BMDMs ) or RAW264.7 macrophages induces marked phosphorylation of LRRK2 at Ser910 and Ser935, the phosphorylation sites that regulate the binding of 14-3-3 to LRRK2