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LRRK2 — TLR4
Text-mined interactions from Literome
Moehle et al., J Neurosci 2012
(Inflammation) :
LRRK2 inhibition
blocks TLR4 stimulated microglial process outgrowth and impairs ADP stimulated microglial chemotaxis
Dzamko et al., PloS one 2012
(Parkinson Disease) :
Here we demonstrate that stimulation of the
Toll-Like Receptor ( TLR ) pathway by MyD88 dependent agonists in bone marrow derived macrophages ( BMDMs ) or RAW264.7 macrophages
induces marked phosphorylation of
LRRK2 at Ser910 and Ser935, the phosphorylation sites that regulate the binding of 14-3-3 to LRRK2