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AKT1 — LRRK2
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Ohta et al., FEBS Lett 2011
(Parkinson Disease) :
A knockdown experiment using intact cells also demonstrated
LRRK2 mediated phosphorylation of
Akt1 ( Ser473 ), suggesting that Akt1 is a convincing candidate for the physiological substrate of LRRK2
Ohta et al., Biochem Biophys Res Commun 2013
(Parkinson Disease) :
Overexpression of WT
LRRK2 in HEK293 cells
increased the phosphorylation level of
Akt1 ( S473 ), a possible physiological substrate of LRRK2, and made cells resistant to hydrogen peroxide induced apoptosis