Gene interactions and pathways from curated databases and text-mining

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AKT1 — LRRK2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Ohta et al., FEBS Lett 2011 (Parkinson Disease) : A knockdown experiment using intact cells also demonstrated LRRK2 mediated phosphorylation of Akt1 ( Ser473 ), suggesting that Akt1 is a convincing candidate for the physiological substrate of LRRK2
Ohta et al., Biochem Biophys Res Commun 2013 (Parkinson Disease) : Overexpression of WT LRRK2 in HEK293 cells increased the phosphorylation level of Akt1 ( S473 ), a possible physiological substrate of LRRK2, and made cells resistant to hydrogen peroxide induced apoptosis