Gene interactions and pathways from curated databases and text-mining

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CASP7 — LRP1

Text-mined interactions from Literome

Campana et al., J Neurosci 2006 (Sciatic Neuropathy) : Silencing of Schwann cell LRP-1 with siRNA decreased phosphorylated Akt and increased activated caspase-3
Fuentealba et al., J Biol Chem 2009 (Neurodegenerative Diseases) : Using lentiviral short hairpin RNA to knock down endogenous LRP1 expression, we showed that a depletion of LRP1 leads to an activation of caspase-3 and increased neuronal apoptosis, an effect that was rescued by a caspase-3 inhibitor