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IGF2 — LPA

Text-mined interactions from Literome

Goetzl et al., Cancer Res 1999 (Breast Neoplasms) : LPA and S1P stimulated BCC secretion of type II insulin-like growth factor ( IGF-II ) by 2-7-fold, to levels at which exogenous IGF-II stimulated increased proliferation and SRE activation of BCCs
Wang et al., Metabolism 2002 : While rhGH appeared not to raise Lp(a) levels among baboons with extremely low levels ( 6.8 +/- 1.1 mg/dL at baseline v 6.6 +/- 0.9 mg/dL, n = 5 ), IGF-1 significantly reduced Lp(a) levels among those with high levels within 2 hours of injection ( 57.0 +/- 6.6 mg/dL v 37.4 +/- 6.2 mg/dL, or a 34 % reduction, n = 3, P =.013 )
Deng et al., J Biol Chem 2004 : B82L cells lack epidermal growth factor receptor (EGFR) but express LPA ( 1-3 ), platelet derived growth factor ( PDGF ), ErbB2, and insulin-like growth factor receptor transcripts, yet LPA caused no detectable transphosphorylation of these receptor tyrosine kinases
Boucharaba et al., Oncol Res 2009 (Breast Neoplasms) : In MDA-BO2 cells, LPA but not S1P activities were dependent on active type 1 insulin-like growth factor and epithelial growth factor receptors