Gene interactions and pathways from curated databases and text-mining

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IGF1 — LPA

Text-mined interactions from Literome

Goetzl et al., Cancer Res 1999 (Breast Neoplasms) : LPA and S1P stimulated BCC secretion of type II insulin-like growth factor ( IGF-II ) by 2-7-fold, to levels at which exogenous IGF-II stimulated increased proliferation and SRE activation of BCCs
Tao et al., Arterioscler Thromb Vasc Biol 1999 (Body Weight) : To determine whether the increase in plasma apo(a) was mediated by IGF-1 , we treated castrated and noncastrated YAC-apo(a) transgenic mice with a continuous infusion of IGF-1 ( 100 microg/d ) for 2 weeks, and plasma levels of apo(a) fell by approximately 50 %
Wang et al., Metabolism 2002 : To explore the mechanisms for the hormonal effects and to search for an effective pharmaceutical agent, we examined the suitability of the baboon as an animal model by investigating the effects of GH and IGF-1 on Lp(a) ... While rhGH appeared not to raise Lp(a) levels among baboons with extremely low levels ( 6.8 +/- 1.1 mg/dL at baseline v 6.6 +/- 0.9 mg/dL, n = 5 ), IGF-1 significantly reduced Lp(a) levels among those with high levels within 2 hours of injection ( 57.0 +/- 6.6 mg/dL v 37.4 +/- 6.2 mg/dL, or a 34 % reduction, n = 3, P =.013 )
Deng et al., J Biol Chem 2004 : B82L cells lack epidermal growth factor receptor (EGFR) but express LPA ( 1-3 ), platelet derived growth factor ( PDGF ), ErbB2, and insulin-like growth factor receptor transcripts, yet LPA caused no detectable transphosphorylation of these receptor tyrosine kinases
Sugimoto et al., Exp Cell Res 2006 : LPA inhibits IGF I-induced Akt activation by only 40 % in a manner dependent on Rho kinase
Boucharaba et al., Oncol Res 2009 (Breast Neoplasms) : In MDA-BO2 cells, LPA but not S1P activities were dependent on active type 1 insulin-like growth factor and epithelial growth factor receptors
Laron et al., Eur J Endocrinol 1997 (Coronary Disease...) : In the present investigation we determined the effects of human growth hormone ( hGH ) and insulin-like growth factor-I (IGF-I) on circulating Lp(a) ... The differential effect of endogenous vs exogenous IGF-I on serum Lp(a) paralleled the behaviour of serum insulin