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IGF1 — LPA
Text-mined interactions from Literome
Goetzl et al., Cancer Res 1999
(Breast Neoplasms) :
LPA and S1P
stimulated BCC secretion of type II
insulin-like growth factor ( IGF-II ) by 2-7-fold, to levels at which exogenous IGF-II stimulated increased proliferation and SRE activation of BCCs
Tao et al., Arterioscler Thromb Vasc Biol 1999
(Body Weight) :
To determine whether the increase in plasma
apo(a) was
mediated by
IGF-1 , we treated castrated and noncastrated YAC-apo(a) transgenic mice with a continuous infusion of IGF-1 ( 100 microg/d ) for 2 weeks, and plasma levels of apo(a) fell by approximately 50 %
Wang et al., Metabolism 2002
:
To explore the mechanisms for the hormonal effects and to search for an effective pharmaceutical agent, we examined the suitability of the baboon as an animal model by investigating the
effects of GH and
IGF-1 on
Lp(a) ... While rhGH appeared not to raise Lp(a) levels among baboons with extremely low levels ( 6.8 +/- 1.1 mg/dL at baseline v 6.6 +/- 0.9 mg/dL, n = 5 ),
IGF-1 significantly
reduced Lp(a) levels among those with high levels within 2 hours of injection ( 57.0 +/- 6.6 mg/dL v 37.4 +/- 6.2 mg/dL, or a 34 % reduction, n = 3, P =.013 )
Deng et al., J Biol Chem 2004
:
B82L cells lack epidermal growth factor receptor (EGFR) but express LPA ( 1-3 ), platelet derived growth factor ( PDGF ), ErbB2, and
insulin-like growth factor receptor transcripts, yet
LPA caused no detectable transphosphorylation of these receptor tyrosine kinases
Sugimoto et al., Exp Cell Res 2006
:
LPA inhibits
IGF I-induced Akt activation by only 40 % in a manner dependent on Rho kinase
Boucharaba et al., Oncol Res 2009
(Breast Neoplasms) :
In MDA-BO2 cells,
LPA but not S1P activities were
dependent on active type 1
insulin-like growth factor and epithelial growth factor receptors
Laron et al., Eur J Endocrinol 1997
(Coronary Disease...) :
In the present investigation we determined the
effects of human growth hormone ( hGH ) and
insulin-like growth factor-I (IGF-I) on circulating
Lp(a) ... The differential
effect of endogenous vs exogenous
IGF-I on serum
Lp(a) paralleled the behaviour of serum insulin