Lee et al., Radiother Oncol 2011
:
Ectopic overexpression of miR-7 attenuated EGFR and Akt expression and radiosensitized SQ20B squamous cell carcinoma of the larynx, MDA-MB-468 breast cancer cells, A549 lung carcinoma cells, and U251 and U87 malignant glioma cells
Wu et al., Chin Med J (Engl) 2011
(Glioblastoma) :
In addition, miR-7 repressed p-ERK1/2 and p-AKT level, MMP-2 and MMP-9 expression
Kalinowski et al., PloS one 2012
(Head and Neck Neoplasms) :
Together, these data support the coordinate regulation of Akt signaling by miR-7 in HNC cells and suggest the therapeutic potential of miR-7 alone or in combination with EGFR TKIs in this disease