Gene interactions and pathways from curated databases and text-mining

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LIFR — MAPK6

Text-mined interactions from Literome

Bartoe et al., J Neurochem 2000 : Coexpression of catalytically inactive, but not wild-type, SHP-2 reduced LIFR- and gp130 mediated activation of MAPK up to 75 %
Schiemann et al., J Biol Chem 1997 : Our results demonstrate that gp130 and LIFR stimulate MAPK activity through box 3-independent mechanisms involving : ( i ) effects at Tyr-118 and Tyr-115, respectively, for maximal stimulation of MAPK activity and ( ii ) a Jak/Tyk dependent pathway that, together with Tyr-118- or Tyr-115 generated signals, converges at the level of Ras during activation of MAPK by cytokine