Gene interactions and pathways from curated databases and text-mining

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LEP — MAPK6

Text-mined interactions from Literome

Takekoshi et al., Endocrinology 2001 : In contrast, leptin did not activate P38 MAPK
Oda et al., Kobe J Med Sci 2001 : Leptin stimulated phosphorylation and activation of mitogen activated protein ( MAP ) kinases , and also increased phosphatidylinositol (PI) 3-kinase activity
Machinal-Quélin et al., Am J Physiol Cell Physiol 2002 (MAP Kinase Signaling System) : Proadipogenic effect of leptin on rat preadipocytes in vitro : activation of MAPK and STAT3 signaling pathways
Bifulco et al., Placenta 2003 (Choriocarcinoma...) : HG culturing also enhanced leptin stimulated insulin receptor substrate 1 (IRS1) and MAPK phosphorylation
Pérez et al., Diabetes 2004 : However, at elevated concentrations, leptin impaired insulin stimulated MAPK activity, glycogen synthase kinase (GSK)3beta phosphorylation, and insulin receptor tyrosine phosphorylation without altering vanadate stimulation
FitzGerald et al., Cell Prolif 2005 (Body Weight...) : Leptin can stimulate mitogen activated protein kinase activity in vitro and short-term infusion has been reported to have a proliferative action on the colon in vivo, suggesting a biological link between obesity, physical activity and colon cancer
Mehebik et al., Am J Physiol Cell Physiol 2005 : Immunoblotting studies have shown that leptin fails to activate Akt but increases p42/p44 MAPK phosphorylation, an effect that is prevented by U0126 but not by H-89
Trujillo et al., J Clin Endocrinol Metab 2006 (Obesity) : The TNF + dex stimulated increase in leptin was associated with an increase in p38 MAPK activity and was totally blocked by p38 MAPK inhibitors
Zhao et al., Cell Immunol 2005 (MAP Kinase Signaling System) : Although gAd partially increased cAMP concentration and PKA activity, it directly reduced leptin induced ERK1/2 and p38 MAPK phosphorylation thus inhibiting TNF-alpha production
Smith et al., Br J Pharmacol 2006 (Myocardial Reperfusion Injury) : Western blotting confirmed that leptin stimulated p44/42 MAPK phosphorylation significantly
Burguera et al., Med Sci Monit 2006 (MAP Kinase Signaling System...) : Interestingly, leptin activated MAPK and the specific MAPK-inhibitor PD98059 blocked DNA synthesis induced by leptin
Cui et al., FASEB J 2006 : We found activation of p38 MAPK by leptin , accompanied by phosphorylation of its downstream effector ATF-1
Sirotkin et al., Comp Biochem Physiol A Mol Integr Physiol 2007 : Finally, leptin inhibited expression of MAPK/ERK1,2 and CDK/p34 and stimulated expression of PKA
Kanda et al., Endocrinology 2008 : IL-1beta or leptin individually induced threonine/tyrosine phosphorylation of p38 MAPK , whereas only leptin induced tyrosine phosphorylation of JAK2, suggesting that leptin may enhance hBD-2 production in keratinocytes by activating STAT1 and STAT3 via JAK2 and p38 MAPK in cooperation with NF-kappaB, which is activated by IL-1beta
Carino et al., Int J Cancer 2008 (Adenocarcinoma...) : Leptin induction of cytokines/receptors generally involved JAK2 and MAPK activation, but PI-3K phosphorylation was required for leptin increase of LIF, IL-1/IL-1R tI
Sharma et al., Eur J Pharmacol 2009 : The aim of the present study was to determine whether nitric oxide and p38 MAPK mediate the stimulation of leptin by MAPK
Arias-Alvarez et al., Reproduction 2010 : The aim of this work was to establish whether : 1 ) leptin influences meiotic and cytoplasmic oocyte maturation ; 2 ) STAT3 and MAPK mediate the effects of leptin and 3 ) leptin modulates steroid secretion by cumulus-oocyte complexes ( COC ) during in vitro maturation ( IVM )
Akasaka et al., Biochim Biophys Acta 2010 : Leptin significantly increased phosphorylation of p38 MAPK , and leptin induced lipid oxidation was abolished by treatment with p38 MAPK siRNA in both types of myotube
Thompson et al., HPB (Oxford) 2011 (Carcinoma, Hepatocellular...) : Immunoblot analysis demonstrated that leptin significantly activated p42/p44-MAPK, p38-MAPK and STAT3 signalling in a time dependent manner
Garonna et al., PloS one 2011 : Inhibition of VEGFR2 tyrosine kinase activity reduced leptin stimulated p38 ( MAPK ) and Akt activation, COX-2 induction, and pro-angiogenic EC responses, and blockade of VEGFR2 or COX-2 activities abolished leptin-driven neo-angiogenesis in a chick chorioallantoic membrane vascularisation assay in vivo
Ge et al., Reproduction 2011 (MAP Kinase Signaling System...) : Inhibition of p38 MAPK with SB203580 not only reduced the basal leptin production but also attenuated the leptin induced production by both hCG and db cAMP
Catalano et al., Am J Pathol 2011 (Breast Neoplasms...) : In addition, PPAR? ligands inhibited leptin signaling mediated by MAPK/STAT3/Akt phosphorylation and counteracted leptin stimulatory effect on estrogen signaling
Yan et al., Mol Med 2012 : p38 MAPK was involved in leptin regulation of SREBP-1c expression in cultured HSCs. Leptin induced activation of p38 MAPK led to the decreases in liver X receptor ( LXR ) -a protein level, activity and its binding to the SREBP-1c promoter, which caused the downregulation of SREBP-1c expression
Sirotkin et al., Animal 2011 : IGF-I, ghrelin and obestatin, but not leptin , when given together with PD98059, increased the accumulation of MAPK in both immature and mature oocytes
Rajapurohitam et al., Mol Cell Biochem 2012 (Hypertrophy) : The ability of both angiotensin II- and endothelin-1 to increase leptin production in cardiomyocytes and the resultant hypertrophic response are mediated by NF-?B and dependent on p38 MAPK activation
Pijet et al., Cytokine 2013 (MAP Kinase Signaling System) : Detailed acute and chronic studies with the use of metabolic inhibitors revealed that both JAK/STAT3 and MEK/MAPK but not PI3-K/AKT/GSK-3ß signaling pathways were activated by leptin , and that STAT3 ( Y ( 705 ) P-STAT3 ) and MEK ( T ( 202/ ) Y ( 204 ) P-ERK1/2 ) mediate these effects
Cha et al., BMB Rep 2012 : We also showed that p38 mitogen activated protein kinase signaling was involved in leptin expression induced by HER2
Tanabe et al., Biochem Biophys Res Commun 1997 (Obesity) : Leptin induces proliferation of pancreatic beta cell line MIN6 through activation of mitogen activated protein kinase
Yamashita et al., Biochem Biophys Res Commun 1998 : As the result of leptin stimulation, enhanced levels of tyrosine phosphorylation of STAT3 and MAPK were detected in CHO-OBRb cells ... We report herein the characterization of activities of signal transduction for three types of leptin receptors ( OBRs ) from rats, the OBRa, OBRb, and OBRb with fa mutation ( OBRb-fa ), by measurement of the levels of tyrosine phosphorylation of STAT3 ( signal transducers and activators of transcription 3 ) and MAPK ( mitogen activated protein kinase ), which are induced by leptin stimulation of CHO cells stably expressing the OBR ( CHO-OBRb, CHO-OBRa, or CHO-OBRb-fa cells )
McCowen et al., Endocrinology 1998 : By contrast, leptin did not increase the phosphorylation of Janus kinase proteins, mitogen activated protein kinase , or STAT1 and -5 despite abundant expression of these signaling molecules in the hypothalamus