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IGF1 — LEP

Text-mined interactions from Literome

Suter et al., J Clin Endocrinol Metab 2000 : Circulating concentrations of nocturnal leptin , growth hormone, and insulin-like growth factor-I increase before the onset of puberty in agonadal male monkeys : potential signals for the initiation of puberty
Martini et al., Bone 2001 : To evaluate the effects of serum IGF-1 and serum leptin on bone mass in healthy postmenopausal women, and the possible role of IGF-1 in leptin production, we studied a population of 123 women, aged 39-82 years
Li et al., Mol Cell Endocrinol 2001 (Glioma) : In contrast, the response of the leptin promoter to insulin, IGF-1 and dibutyryl cAMP was cell-type specific and dependent on the presence or absence of FBS in the culture medium ... Insulin, IGF-1 and dibutyryl cAMP each caused an approximately two-fold stimulation of leptin promoter activity in 3T3-L1 cells under serum-free conditions, but had no significant effect in the presence of 10 % FBS
Huang et al., Zhonghua Fu Chan Ke Za Zhi 2002 : To assess the effects of leptin on follicle stimulating hormone ( FSH ) and insulin-like growth factor-I (IGF-I) induced production of estradiol ( E ( 2 ) ) -17beta and progesterone ( P ) in cultured human luteinized granulosa cell ( GC ) ... Leptin significantly inhibited FSH + IGF-I or IGF-I induced E ( 2 ) production ... Leptin may directly attenuate the IGF-I or IGF-I and FSH stimulated E ( 2 ) synthesis in cultured human luteinized GC by the leptin receptor mechanism
Cornish et al., J Endocrinol 2002 : Leptin ( > 10 ( -11 ) m ) increased proliferation of isolated fetal rat osteoblasts comparably with IGF-I , and these cells expressed the signalling form of the leptin receptor
Ajuwon et al., J Nutr Biochem 2003 : The regulation of IGF-1 by leptin in the pig is tissue specific and independent of changes in growth hormone ... A combination of in vivo and in vitro experiments were performed to determine the extent to which exogenous leptin regulates serum growth hormone (GH) and insulin-like growth factor I (IGF-1) concentrations, and the abundance of IGF-1 mRNA in major peripheral tissues ... Leptin ( 100 nM ) caused a sharp reduction ( P < 0.0001 ) in dexamethasone induced IGF-1 secretion at 24 hr ( 47 % reduction ) and at 48 hr ( 40 % reduction ) ... Collectively, these data indicate that leptin may regulate hepatic IGF-1 production in the pig, independent of GH, but that hepatocyte sensitivity to leptin may be depend on dose and in vitro vs. in vivo conditions
Kilic et al., Clin Biochem 2004 (Kwashiorkor...) : The decrease of energy intake and adipose tissue and serum IGF-1 levels in children with PEM may result in decrease of leptin secretion
Kiess et al., Regul Pept 2005 : ( 2 ) Added exogenous leptin does not affect IGF-I , IGFBP-2 or IGF-I receptor mRNA expression and IGF-I and IGFBP-2 secretion by SK-N-MC cells in vitro under the conditions studied
Garofalo et al., Clin Cancer Res 2006 (Breast Neoplasms...) : The effects of insulin, IGF-I , estradiol, and hypoxia on leptin and ObR mRNA expression were assessed by reverse transcription-PCR in MCF-7 and MDA-MB-231 breast cancer cell lines
Gregoraszczuk et al., Acta Vet Hung 2006 : In conclusion, we infer that ( 1 ) leptin directly affects ovarian function in prepubertal animals by its action on oestradiol secretion and cell apoptosis, ( 2 ) GH and IGF-I modulate the action of leptin, and ( 3 ) at least in part, the direct effect of GH/IGF-I on leptin production is due to an action on leptin receptor expression
Tennekoon et al., Fertil Steril 2007 : Effect of leptin on prolactin and insulin-like growth factor-I secretion by cultured rat endometrial stromal cells ... To study the possible effect of leptin on PRL and insulin-like growth factor (IGF)-I secretion from rat endometrial stromal cells ... The effect of recombinant murine leptin on the secretion of PRL and IGF-I by cultured rat endometrial cells was investigated ... Leptin did not significantly affect IGF-I secretion either in a dose- or a time dependent manner
Nindl et al., J Appl Physiol 2007 (Body Weight...) : Total and free IGF-I, IGF binding proteins-1, -2, and -3, the acid labile subunit, transferrin, ferritin, retinol binding protein, prealbumin, testosterone, triiodothyronine, thyroxine, and leptin responses were measured
Martin et al., Endocrinology 2007 (Body Weight) : High-dose leptin ( but not low ) induced a decrease in body-weight abdominal fat mass and serum IGF-I levels
Gad et al., Saudi Med J 2007 (Diabetes Mellitus, Experimental) : Combined leptin and insulin treatment produced a significant increase of serum BAP and a decrease of urinary calcium and serum glucose as compared to rats treated by leptin only, and a significant increase of BAP, alkaline phosphates, IGF-1 , and glucose and a decrease in osteocalcin as compared to control rats
Chan et al., J Clin Endocrinol Metab 2008 : Leptin does not mediate short-term fasting induced changes in growth hormone pulsatility but increases IGF-I in leptin deficiency states
Kim et al., Endocr J 2008 : Taken together, results suggest the anti-lipogenic and lipolytic effects of leptin in differentiating and mature adipocytes may have been partly mediated by suppressing the expression of PPAR-gamma and IGF-I genes
Ozbay et al., Mol Cancer Res 2008 (Breast Neoplasms) : In contrast to IGF-I, leptin did not induce phosphorylation of IGF-IR , indicating that receptor cross signaling is unidirectional, occurring from IGF-IR to Ob-R
Saxena et al., Cancer Res 2008 (Breast Neoplasms...) : We found a novel bidirectional crosstalk between leptin and IGF-I signaling ; IGF-I induced phosphorylation of leptin receptor ( Ob-Rb ) and leptin induced phosphorylation of IGF-I receptor (IGF-IR), whereas cotreatment induced synergistic phosphorylation and association of Ob-Rb and IGF-IR along with activation of downstream effectors, Akt and extracellular signal regulated kinase ... We found a novel bidirectional crosstalk between leptin and IGF-I signaling ; IGF-I induced phosphorylation of leptin receptor ( Ob-Rb ) and leptin induced phosphorylation of IGF-I receptor (IGF-IR), whereas cotreatment induced synergistic phosphorylation and association of Ob-Rb and IGF-IR along with activation of downstream effectors, Akt and extracellular signal regulated kinase
Sirotkin et al., Theriogenology 2009 : In in vitro experiments, leptin significantly decreased ( at 1 and 10 ng/mL ) or increased ( at 100 ng/mL ) P ( 4 ) secretion, promoted E ( 2 ) and IGF-I ( both at 100 ng/mL ) secretion, and reduced T ( at 1 and 10 ng/mL ) and PGF ( at 10 ng/mL ) secretion
Pallu et al., Arthritis Res Ther 2010 (Obesity...) : Higher leptin levels induced the expression of IGF-1 , type 2 collagen, TIMP-2 and MMP-13
Khan et al., Yonsei Med J 2012 (Amenorrhea) : Leptin deficiency results in decreased insulin-like growth factor 1 levels which can be partially ameliorated through leptin administration, and leptin appears to have a much more pronounced effect on the growth of rodents than that of humans
Jørgensen et al., J Exp Biol 2013 : In an in vitro study with liver slices it was shown that recombinant rainbow trout leptin stimulated SOCS1 and SOCS3 expression, but not SOCS2, IGF-I or genes of enzymes involved in lipid ( G6PDH ) and amino acid ( AspAT ) metabolism
Zachow et al., Endocrinology 1997 : Leptin caused a dose dependent ( IC50 = 2.7 +/- 0.6 ng/ml ) inhibition ( 30-50 % ) of the IGF-I increase in FSH stimulated E2 production
Chen et al., Obes Res 1998 : These results demonstrated that regulation of leptin mRNA expression by Dex, insulin, IGF-I , TGF-beta, and GH may be associated with changes in preadipocyte number and fat cell size ... These results demonstrated that regulation of leptin mRNA expression by Dex, insulin, IGF-I , TGF-beta, and GH may be associated with changes in preadipocyte number and fat cell size
Fouque et al., Kidney Int 1998 (Kidney Failure, Chronic) : Acute leptin regulation in end-stage renal failure : the role of growth hormone and IGF-1
Miyakawa et al., J Clin Endocrinol Metab 1998 (Acromegaly) : These data suggest that excess GH/insulin-like growth factor I reduces serum leptin levels by reducing body fat mass and/or by unknown mechanisms
Spurlock et al., J Interferon Cytokine Res 1998 : These data indicate that changes in IGF-1 status in endotoxin challenged pigs are independent of serum GH and that leptin expression is not increased by endotoxin challenge in the pig