Gene interactions and pathways from curated databases and text-mining

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HIF1A — LEP

Text-mined interactions from Literome

Grosfeld et al., J Biol Chem 2002 (Choriocarcinoma) : Deletion analysis and site-specific mutagenesis demonstrated that a HIF-1 consensus binding site ( HRE ) spanning -120 to -116 bp relative to the start site was required for CoCl2 and exogenous HIF-1alpha induction of leptin promoter activity
Wu et al., Am J Pathol 2007 (Endometriosis) : A promoter activity assay demonstrated that HIF-1alpha induced leptin promoter activity after DFO treatment ... Taken together, our data demonstrate that aberrant expression of leptin in ectopic endometriotic stromal cells is induced , at least in part, by an elevated level of HIF-1alpha in these cells, providing new insights into the etiology of endometriosis
Zhang et al., Zhonghua Yi Xue Za Zhi 2008 (Adenocarcinoma...) : The expression of leptin is up-regulated by hypoxia and regulated by HIF-1alpha
Gonzalez-Perez et al., Cell Signal 2010 (Mammary Neoplasms, Experimental) : Deletion analysis of VEGF promoter and RNA knockdown shows that HIF-1alpha and NFkappaB are essentials for leptin regulation of VEGF ... Leptin activation of HIF-1alpha was mainly linked to canonic ( MAPK, PI-3K ) and non-canonic ( PKC, JNK and p38 MAP ) signalling pathways