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AKT1 — LEP

Text-mined interactions from Literome

Goetze et al., Hypertension 2002 : Leptin induces endothelial cell migration through Akt , which is inhibited by PPARgamma-ligands ... Both PPARgamma-ligands inhibited leptin stimulated Akt and eNOS phosphorylation, but neither attenuated ERK 1/2 activation in response to leptin
Somasundar et al., J Surg Res 2004 (Prostatic Neoplasms) : Leptin up-regulated p-Akt in a time- and dose dependent manner in the DU145 prostate cancer cells via a suppression of apoptosis
Lang et al., Biochem Biophys Res Commun 2004 : Instead, leptin increased phospho-Akt levels in HSCs within 30 min, suggesting that the phosphatidylinositol 3 kinase (PI3K)/Akt pathway is involved in the mechanism by which leptin accelerates the proliferation of HSCs
Brabant et al., FASEB J 2005 (Insulin Resistance...) : Only in lean animals phosphorylation of PKB ( T308 ) and GSK-3beta ( S9 ) was acutely stimulated by leptin at 45 min followed by inhibition at 6 h after application
Sharma et al., Endocr Relat Cancer 2006 (Endometrial Neoplasms...) : Moreover, leptin induced phosphorylation of ERK2 and AKT was dependent on JAK/STAT activation
Ogunwobi et al., Int J Colorectal Dis 2007 (Colonic Neoplasms) : Stimulation of HT-29 cells with leptin increased phosphorylation of JAK2, Akt and JNK
Rodríguez et al., Endocrinology 2007 : Leptin also significantly increased STAT3 ( P < or = 0.01 ) and Akt ( P < or = 0.001 ) phosphorylation
Hoda et al., Br J Surg 2007 (Colonic Neoplasms...) : Leptin also caused ERK1/2 and Akt phosphorylation
Bełtowski et al., Regul Pept 2007 : Leptin stimulated Akt phosphorylation at Ser ( 473 ) in aortic tissue but not in the kidney
Saxena et al., Cancer Res 2007 (Carcinoma, Hepatocellular...) : Leptin induced phosphorylation of ERK and AKT was dependent on Janus activated kinase ( JAK ) /STAT activation
Beales et al., BMC cancer 2007 (Adenocarcinoma...) : Akt activation promotes proliferation and inhibits apoptosis in Barrett 's adenocarcinoma cells and both transient acid exposure and leptin stimulate Akt phosphorylation
Zeidan et al., J Pharmacol Exp Ther 2007 (Hypertrophy) : Our results indicate that the activation of RhoA/ROCK and PI3K/Akt plays a pivotal role in leptin signaling, leading to the development of VSMC hypertrophy through a mechanism involving altered actin dynamics
Lam et al., J Biol Chem 2007 : Leptin induces CD40 expression through the activation of Akt in murine dendritic cells
Ogunwobi et al., Mol Cell Endocrinol 2008 (Adenocarcinoma...) : Adiponectin inhibited leptin induced Akt phosphorylation ; this action was sensitive to okadaic acid but not to Compound C. Adiponectin deficiency may contribute to the promotion of OAC in obesity
Garza et al., J Biol Chem 2008 : Analysis of signal transduction pathways revealed that leptin stimulated phosphorylation of Akt and STAT3 but not ERK1/2
Miyazaki et al., Biochim Biophys Acta 2008 (Prostatic Neoplasms) : Leptin activates JNK, STAT3 and Akt in a biphasic manner with a similar time-course ... Moreover, JNK inhibition impairs leptin stimulated Ser-473 phosphorylation of Akt that is required for its activation ... Thus, JNK is involved in leptin stimulated Akt activation
De Minicis et al., Hepatology 2008 (Disease Models, Animal...) : Leptin induced phosphorylation of extracellular signal regulated kinase ( ERK ) and AKT , but not of STAT3, was blocked by NADPH oxidase inhibition
Gao et al., Cancer Sci 2009 (Endometrial Neoplasms) : We also showed that leptin stimulated cell proliferation and induced activations of signal transducers and activators of transcription 3 ( STAT3 ), extracellular signal regulated kinase ( ERK1/2 ), AKT , and cyclooxygenase (COX)-2 in endometrial cancer cells dose-dependently by [ ( 3 ) H ] thymidine incorporation assay and western blotting
Procopio et al., Endocrinology 2009 : siRNA mediated down-regulation of AMPKalpha1, but not AMPKalpha2, abolished leptin induced Akt-Ser ( 473 ) phosphorylation, eNOS-Ser ( 1177 ) phosphorylation, eNOS activation, and cGMP accumulation ... By contrast, siRNA mediated knockdown of Akt1 did not affect AMPKalpha1 phosphorylation, but it abolished leptin induced phosphorylation of Akt-Ser ( 473 ) and eNOS-Ser ( 1177 ), suggesting that Akt functions downstream of AMPKalpha1
Won et al., Obesity (Silver Spring) 2009 (Obesity) : ICV administration of TG by itself activated signal-transduction-activated-transcript-3 ( STAT3 ) and Akt in the hypothalamus, but prevented a further activation of hypothalamic STAT3 and Akt by leptin and insulin
Fang et al., Diabetologia 2009 : Adiponectin can also enhance insulin sensitivity via direct signalling crosstalk ; here we show that enhanced insulin stimulated IRS-1 ( Y612 ) and Akt ( T308 ) phosphorylation in response to fAd was attenuated by leptin
Roman et al., Mol Cell Endocrinol 2010 : We concluded that the activation of the hypothalamic PI3K pathway is important for leptin induced AKT phosphorylation, as well as for active catabolic pathway through AMPK and PGC1 alpha in SM
Bełtowski et al., Peptides 2010 (Obesity) : Leptin stimulated Akt phosphorylation at Ser ( 473 ) in aortic tissue but not in the kidney, and this effect was comparable in control and hyperleptinemic groups
Uddin et al., Endocr Relat Cancer 2010 (Carcinoma, Papillary...) : Inhibition of PI3K activity by its inhibitor LY294002 abrogated leptin mediated PI3K/AKT signaling
Sharma et al., Hepatology 2010 (Carcinoma, Hepatocellular...) : Analysis of the underlying molecular mechanisms revealed that adiponectin treatment reduced leptin induced Stat3 and Akt phosphorylation
Choi et al., Carcinogenesis 2011 (Ovarian Neoplasms) : To examine an involvement of Janus kinase 2/signal transducers and activators of transcription 3 ( STAT-3 ) and phosphatidyl-inositol 3-kinase (PI3K)/Akt in leptin induced pathway, we demonstrated that leptin increased phosphorylation of STAT-3 and Akt in BG-1 cells in a time- and dose dependent manner
Lin et al., PloS one 2011 (Disease Progression...) : Akt knockdown, and inhibition of Akt signaling by LY294002 and mTOR inhibitor rapamycin reduced leptin expression ... These results suggest that Akt and C/EBP a activation were involved in AA-regulated leptin expression
Garonna et al., PloS one 2011 : Inhibition of VEGFR2 tyrosine kinase activity reduced leptin stimulated p38 ( MAPK ) and Akt activation, COX-2 induction, and pro-angiogenic EC responses, and blockade of VEGFR2 or COX-2 activities abolished leptin-driven neo-angiogenesis in a chick chorioallantoic membrane vascularisation assay in vivo
Catalano et al., Am J Pathol 2011 (Breast Neoplasms...) : In addition, PPAR? ligands inhibited leptin signaling mediated by MAPK/STAT3/Akt phosphorylation and counteracted leptin stimulatory effect on estrogen signaling
Cheng et al., Oncol Rep 2011 (Carcinoma...) : We showed that leptin induced AKT and extracellular signal regulated kinase ( ERK ) phosphorylation
Faulhaber-Walter et al., Diabetes 2011 (Body Weight...) : Effects were not triggered by leptin deficiency but involved a decreased Akt phosphorylation
Guo et al., Int J Neuropsychopharmacol 2013 : In accordance with this, leptin stimulated phosphorylation of Akt was attenuated in the hippocampus of AAV-Cre injected mice
Li et al., PloS one 2012 : Mechanistically, leptin induced the phosphorylation of STAT3, Akt and ERK1/2 accompanied by the upregulation of cyclin D1
Liu et al., Zhonghua Jie He He Hu Xi Za Zhi 2012 : The results also showed that leptin significantly increased phosphorylation of Akt that positively related to leptin concentration ( r = 0.958, P < 0.05 )
Taliaferro-Smith et al., Neoplasia (New York, N.Y.) 2013 (Breast Neoplasms...) : Pretreatment of breast cancer cells with adiponectin protects against leptin induced activation of ERK and Akt
Nazarians-Armavil et al., Mol Endocrinol 2013 : Leptin directly repressed agouti related peptide mRNA levels but induced urocortin-2, insulin receptor substrate (IRS)-1, IRS2, and IR transcription, through leptin mediated phosphatidylinositol 3-kinase/Akt activation
Barthel et al., Endocrinology 1997 (Obesity) : The aim of this study was to investigate the role of Akt in the production of leptin by adipocytes ... These results indicate that Akt can induce leptin production in 3T3-L1 adipocytes via a non-transcriptional mechanism