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LDLR — MAPK6

Text-mined interactions from Literome

Singh et al., J Biol Chem 1999 : Inhibition of p38 ( MAPK ) induces low density lipoprotein receptor expression through activation of the p42/44(MAPK) cascade ... Consistent with this finding, selective activation of the p38 ( MAPK ) signaling pathway by expression of MKK6b ( E ), a constitutive activator of p38 ( MAPK ), significantly reduced LDL receptor promoter activity ... Expression of the p38 ( MAPK ) alpha-isoform had a similar effect, whereas expression of the p38 ( MAPK ) betaII-isoform had no significant effect on LDL receptor promoter activity ... SB202190 dependent increase in LDL receptor expression was accompanied by induction of p42/44(MAPK) , and inhibition of this pathway completely prevented SB202190 induced LDL receptor expression, suggesting that p38 ( MAPK ) negatively regulates the p42/44(MAPK) cascade and the responses mediated by this kinase
Mehta et al., Trends Cardiovasc Med 1999 (Hypercholesterolemia) : Our recent demonstration that stress activated p38MAPK negatively regulates LDL receptor expression in an isoform-specific manner via modulation of p42/44MAPK cascade represents a new dimension of complexity in the molecular communication that governs LDL receptor expression
Kapoor et al., J Lipid Res 2003 : pp90RSK- and protein kinase C-dependent pathway regulates p42/44MAPK induced LDL receptor transcription in HepG2 cells ... The present studies were designed to delineate the molecular mechanisms underlying p42/44MAPK induced LDL receptor transcription in HepG2-Delta Raf-1 : ER cells, a modified HepG2 cell line in which the Raf-1/MEK/p42/44MAPK cascade can be specifically activated by anti-estradiol ICI182,780 in an agonist-specific manner
Mulvihill et al., Diabetes 2011 (Atherosclerosis...) : In HepG2 cells, activation of mitogen activated protein kinase-extracellular signal related kinase signaling by nobiletin or insulin increased LDLR and decreased MTP and DGAT1/2 mRNA, resulting in marked inhibition of apoB100 secretion
Kumar et al., J Biol Chem 1998 : Differential roles of extracellular signal regulated kinase-1/2 and p38 ( MAPK ) in interleukin-1beta- and tumor necrosis factor-alpha induced low density lipoprotein receptor expression in HepG2 cells ... In contrast, SB202190, a specific inhibitor of p38 ( MAPK ), enhanced IL-1beta induced LDL receptor expression, with a concomitant increase in ERK-1/2 activity ... These results show that IL-1beta- or TNF induced LDL receptor expression requires ERK-1/2 activation, that the p38 ( MAPK ) pathway negatively regulates LDL receptor expression, and that sterols inhibit induction at a point downstream of ERK-1/2 in HepG2 cells