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IGF1 — LDLR
Text-mined interactions from Literome
Ostlund et al., Mol Endocrinol 1994
:
To identify a molecular basis for this observation, the
effects of
IGF-I on
LDL receptor expression in fibroblasts were studied
Parini et al., Endocrinology 1995
(Carcinoma, Hepatocellular...) :
Although incubation with insulin-like growth factor-I (IGF-I) stimulated LDL receptor expression, the hGH induced stimulation was unaltered after preincubation of cells with a monoclonal mouse anti-IGF-I antibody, suggesting that the release of
IGF-I is not
involved in
LDL receptor stimulation by hGH
Streicher et al., J Biol Chem 1996
:
SREBP-1 mediates
activation of the
low density lipoprotein receptor promoter by insulin and
insulin-like growth factor-I
LaVoie et al., Endocrinology 1999
:
Concerted
regulation of
low density lipoprotein receptor gene expression by follicle stimulating hormone and
insulin-like growth factor I in porcine granulosa cells : promoter activation, messenger ribonucleic acid stability, and sterol feedback ... To determine whether and how
IGF-I and FSH
control the genomic expression of the
LDL receptor , we evaluated their individual and concerted effects on LDL receptor messenger RNA ( mRNA ) accumulation, stability, and gene promoter activity in first passage monolayer ( serum-free ) cultures of porcine granulosa cells ... Ribonuclease protection assays revealed that
LDL receptor mRNA accumulation was
increased by human recombinant
IGF-I ( 100 ng/ml ), FSH ( 25 ng/ml NIDDK oFSH-20 ), or their combination by 2.2-, 2.6-, and 4.6-fold, respectively ( P < 0.01 )