Gene interactions and pathways from curated databases and text-mining

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IGF1 — LDLR

Text-mined interactions from Literome

Ostlund et al., Mol Endocrinol 1994 : To identify a molecular basis for this observation, the effects of IGF-I on LDL receptor expression in fibroblasts were studied
Parini et al., Endocrinology 1995 (Carcinoma, Hepatocellular...) : Although incubation with insulin-like growth factor-I (IGF-I) stimulated LDL receptor expression, the hGH induced stimulation was unaltered after preincubation of cells with a monoclonal mouse anti-IGF-I antibody, suggesting that the release of IGF-I is not involved in LDL receptor stimulation by hGH
Streicher et al., J Biol Chem 1996 : SREBP-1 mediates activation of the low density lipoprotein receptor promoter by insulin and insulin-like growth factor-I
LaVoie et al., Endocrinology 1999 : Concerted regulation of low density lipoprotein receptor gene expression by follicle stimulating hormone and insulin-like growth factor I in porcine granulosa cells : promoter activation, messenger ribonucleic acid stability, and sterol feedback ... To determine whether and how IGF-I and FSH control the genomic expression of the LDL receptor , we evaluated their individual and concerted effects on LDL receptor messenger RNA ( mRNA ) accumulation, stability, and gene promoter activity in first passage monolayer ( serum-free ) cultures of porcine granulosa cells ... Ribonuclease protection assays revealed that LDL receptor mRNA accumulation was increased by human recombinant IGF-I ( 100 ng/ml ), FSH ( 25 ng/ml NIDDK oFSH-20 ), or their combination by 2.2-, 2.6-, and 4.6-fold, respectively ( P < 0.01 )