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IL12A — KLRB1

Text-mined interactions from Literome

Poggi et al., J Immunol 1999 (Multiple Sclerosis) : IL-12 mediated NKRP1A up-regulation and consequent enhancement of endothelial transmigration of V delta 2+ TCR gamma delta+ T lymphocytes from healthy donors and multiple sclerosis patients ... No up-regulation of NKRP1A by IL-12 was noted on V delta 1+ clones ... We conclude that the expression of NKRP1A on V delta 2+ cells is associated with increased ability to migrate across the vascular endothelium and that this phenomenon may be regulated by IL-12 present in the microenvironment
Poggi et al., Eur J Immunol 1998 : IL-12 induced up-regulation of NKRP1A expression in human NK cells and consequent NKRP1A mediated down-regulation of NK cell activation ... IL-12 , in contrast to IL-2, strongly up-regulated the expression of the NKRP1A lectin molecule on human NK cells ... The IL-12 induced NKRP1A expression was time and dose dependent, reaching a maximum by 7 days of culture in the presence of 2 ng/ml IL-12 and it was inhibited by the addition of anti-IL-12 monoclonal antibody ... The IL-12 dependent NKRP1A up-regulation was abrogated by the incubation of NK cells with actinomycin D, thus suggesting that IL-12 induces de novo transcription of NKRP1A mRNA
Azzoni et al., J Immunol 1998 : Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells ... CD161 transcription, mRNA accumulation, and surface expression are increased by IL-12