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KLF5 — MAPK6

Text-mined interactions from Literome

Usui et al., J Biol Chem 2004 (MAP Kinase Signaling System) : Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK dependent induction of Kruppel-like factor 5
Mori et al., Mol Cancer Res 2009 (Pancreatic Neoplasms) : Surprisingly, inhibition of B-Raf/C-Raf or MAPK/Erk did not reduce KLF5 levels, suggesting that KLF5 expression is not promoted by KRAS-Raf-MEK-Erk signaling in pancreatic cancer ... In conclusion, overexpression of KLF5 in human pancreatic cancer cells is not mediated by KRAS/Raf/MAPK/Erk signaling, but involves the IL-1beta/IL-1R system, p38, and the transcription factor HIF-1alpha