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IGF1 — KL
Text-mined interactions from Literome
Kurosu et al., Science 2005
(Insulin Resistance) :
Alleviation of aging-like phenotypes in Klotho-deficient mice was observed by perturbing insulin and IGF1 signaling, suggesting that
Klotho mediated inhibition of insulin and
IGF1 signaling contributes to its anti aging properties
Yamamoto et al., J Biol Chem 2005
:
Thus,
Klotho induced inhibition of
insulin/IGF-1 signaling is associated with increased resistance to oxidative stress, which potentially contributes to the anti aging properties of klotho
Li et al., Rejuvenation Res 2008
(Calcium Signaling...) :
Our data suggest that regulation of Akt, p53, adenosine monophosphate activated protein kinase ( AMPK ) phosphorylation, and
Klotho may
play a role, at least in part, in
IGF-1 deficiency induced `` desensitization '' of cardiac aging
Château et al., Aging 2010
:
While membrane bound Klotho, which is primarily expressed in the kidney, acts as an obligate co-receptor of FGF23 to regulate phosphate homeostasis, secreted
Klotho , resulting from the shedding of the KL1-KL2 ectodomain into the bloodstream,
inhibits Insulin/IGF1 signalling
Doi et al., J Biol Chem 2011
(Fibrosis...) :
In addition to TGF-ß1 signaling, secreted
Klotho has been shown to
inhibit Wnt and
IGF-1 signaling that can promote EMT
Abramovitz et al., Clin Cancer Res 2011
(Adenocarcinoma...) :
KL1 internal repeat mediates
klotho tumor suppressor activities and
inhibits bFGF and
IGF-I signaling in pancreatic cancer ...
Klotho is expressed in the normal pancreas and both the
IGF-I and FGF pathways are
involved in pancreatic cancer development ... Overexpression of
klotho , or treatment with soluble klotho, reduced growth of pancreatic cancer cells in vitro and in vivo, and
inhibited activation of the
IGF-I and the bFGF pathways
Shu et al., Cellular oncology (Dordrecht) 2013
(Carcinoma, Hepatocellular...) :
Exogenous
klotho gene expression also
down-regulated the phosphorylation levels of the
IGF-1 receptor, and the downstream Akt, ERK, and p70S6K proteins