Beauchamp et al., Free Radic Biol Med 2004
(Retinal Diseases) :
Interestingly, VEGFR-2 expression was respectively increased by NOS inhibition after short-term ( 2 days ) exposure to hyperoxia and decreased during the longer hyperoxia exposure
Camp et al., Clin Cancer Res 2006
(Neovascularization, Pathologic...) :
Although VEGFR-2 can mediate NOS activity, the combination of VEGFR-2 and NOS inhibition significantly increased the antivascular effect over single agent therapy