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KDR — MAPK3
Text-mined interactions from Literome
Hata et al., Diabetes 1999
:
MAPK inhibitor PD98059
reduced KDR mRNA expression 72 % at concentrations that inhibited bFGF induced MAPK phosphorylation 100 %, suggesting that pathways in addition to MAPK might also be involved
Wu et al., J Biol Chem 2000
:
MEK, PLCgamma, and to a lesser extent PKC, are in the pathway through which
KDR activates
MAPK
Kim et al., J Biol Chem 2002
:
Endostatin blocked VEGF induced tyrosine phosphorylation of
KDR/Flk-1 and
activation of ERK, p38
MAPK , and p125(FAK) in human umbilical vein endothelial cells
Larrivée et al., J Biol Chem 2003
(MAP Kinase Signaling System) :
Although
VEGFR-2 also
activated Erk1/2 mitogen activated protein kinase, it did not induce cell proliferation, and blockade of this pathway only partially decreased VEGFR-2 mediated survival of hematopoietic progenitors
Zeng et al., J Biol Chem 2003
:
Our results further indicate that Gq/11 proteins specifically mediate
KDR signaling such as intracellular Ca2+ mobilization rather than Flt-1 induced CDC42 activation and that a Gq/11 antisense oligonucleotide completely
inhibits MAPK phosphorylation induced by KDR but has no effect on Flt-1 induced MAPK activation
Sun et al., Cancer Res 2004
(Lung Neoplasms...) :
GFA-116 inhibits VEGF stimulated
Flk-1 tyrosine phosphorylation and subsequent activation of
Erk1/2 mitogen
activated protein kinases
Lamy et al., Carcinogenesis 2006
(Neoplasms) :
Inhibition of
VEGFR-2 by delphinidin
inhibited the VEGF induced activation of
ERK-1/2 signaling and the chemotactic motility of human EC as well as their differentiation into capillary-like tubular structures in Matrigel and within fibrin gels
Ferrari et al., Proc Natl Acad Sci U S A 2006
:
Inhibition of p38 ( MAPK ) blocks TGF-beta1 induced apoptosis, showing that
VEGF/flk-1 mediated activation of p38 (
MAPK ) is required for TGF-beta1 induction of apoptosis ... However, in context with TGF-beta1,
VEGF/flk-1 mediated activation of p38 (
MAPK ) results in apoptosis
Ling et al., Biochem Biophys Res Commun 2007
(Carcinoma, Lewis Lung) :
Endostar suppressed the VEGF induced tyrosine phosphorylation of KDR/Flk-1 ( VEGFR-2 ) as well as the overall
VEGFR-2 expression and the
activation of ERK, p38
MAPK , and AKT in HUVECs
Grummer et al., Biochem J 2009
:
Although VEGF ( 165 ) also activates ERK ( extracellular-signal regulated kinase ) -1/2, this is not necessary for eNOS activation since U0126 blocks ERK-1/2 phosphorylation, but not eNOS activation, and the
VEGFR-2 kinase inhibitor
inhibits eNOS activation, but not
ERK-1/2 phosphorylation
Samuel et al., Diabetes 2010
(Diabetes Mellitus, Experimental...) :
We also observed increased phosphorylated
mitogen activated protein kinase activated protein kinase-2, 2 days after the treatment and increased expression of vascular endothelial growth factor ( VEGF ),
Flk-1 , angiopoietin-1 (Ang-1), Tie-2, and survivin, 4 days after treatment in the diabetic animals
Garonna et al., PloS one 2011
:
Inhibition of
VEGFR2 tyrosine kinase activity
reduced leptin stimulated p38 (
MAPK ) and Akt activation, COX-2 induction, and pro-angiogenic EC responses, and blockade of VEGFR2 or COX-2 activities abolished leptin-driven neo-angiogenesis in a chick chorioallantoic membrane vascularisation assay in vivo
Murakami et al., J Clin Invest 2011
(Ischemia) :
Transcriptional analysis revealed that Ets transcription factors controlled
VEGFR2 expression in an FGF- and
Erk1/2 dependent manner
Belugali Nataraj et al., Cell Signal 2013
(Breast Neoplasms...) :
NAP is phosphorylated by VEGF
induced activation of
MAPK and JNK pathways through
VEGFR2 phosphorylation