Gene interactions and pathways from curated databases and text-mining

◀ Back to ARF6

ARF6 — KDM6B

Text-mined interactions from Literome

Barradas et al., Genes Dev 2009 : In human fibroblasts, JMJD3 activates INK4a, but not ARF , and causes p16(INK4a) dependent arrest ... In mouse embryo fibroblasts, Jmjd3 activates both Ink4a and Arf and elicits a p53 dependent arrest, echoing the effects of RAS in this system ... Our findings directly implicate JMJD3 in the regulation of INK4a/ARF during oncogene induced senescence and suggest that JMJD3 has the capacity to act as a tumor suppressor
Solá et al., PloS one 2011 : In addition, the histone H3 lysine 27-specific demethylase JMJD3 induces ARF expression, thereby stabilizing p53 in mouse embryonic fibroblasts