Gene interactions and pathways from curated databases and text-mining

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CASP5 — JAK3

Text-mined interactions from Literome

Russo et al., Endocrinology 2004 (Neuroblastoma) : Leptin 's antiapoptotic activity required Janus kinase/STAT , MAPK, and phosphatidylinositol-3-kinase activation because the antiapoptotic effects of leptin were abolished, and caspase-3 immunoreactivity increased in the presence of the specific blockers AG490, U0126, or LY294002
Hussner et al., Mol Pharmacol 2012 (Neoplasms) : Furthermore, inhibition of JAK-STAT signaling significantly reduced doxorubicin induced caspase 3 activation and desensitized HeLa cells to doxorubicin cytotoxicity