Gene interactions and pathways from curated databases and text-mining

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IGF2 — JAK2

Text-mined interactions from Literome

Ray et al., Int J Oncol 2007 (Breast Neoplasms...) : MCF-7 cells expressed higher levels of Ob-Rb, Jak2 , PI3K, Stat3 and p-Stat3 in a dose dependent manner to 50 ng/ml at 24 h ; and IGF-IRalpha increased at 24 h. Cyclin D1 and Cox-2 levels increased with leptin treatment
Wang et al., J Biol Chem 2008 : Interestingly, the expression of the IGF2 gene and the HGF gene is also regulated by JAK2/STAT2/STAT3 , suggesting that this pathway could also promote differentiation by regulating signaling molecules known to be involved in myogenic differentiation