Gene interactions and pathways from curated databases and text-mining

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JAK1 — TLR4

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Walker et al., Arch Virol Suppl 2005 (Ehrlichiosis) : Ehrlichiae attach to L-selectin and E-selectin, inhibit phagolysosomal fusion, apoptosis, and JAK/STAT activation, and downregulate IL-12, IL-15, IL-18, TLR2 and 3, and CD14
Huynh et al., J Immunol 2012 (MAP Kinase Signaling System) : We investigated mechanisms by which ITAM associated receptors inhibit type I IFN ( IFN-a/ß ) signaling in primary human macrophages and tested the effects of simultaneous ligation of ITAM associated receptors and TLR4 on TLR4 induced Jak-STAT signaling that is mediated by autocrine IFN-ß