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AKT1 — JAK1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Oki et al., Blood 2002
(Cell Transformation, Neoplastic) :
These results suggest that
Jak1 dependent
Akt activation is important in v-Abl mediated transformation
Song et al., Chin J Cancer 2002
(Multiple Myeloma) :
IL-6 inhibited apoptosis of XG-7 cells through up-regulation of Mcl-1 and the
activation of
JAK/STAT rather than Ras/MAPK nor
PI-3K/Akt signal transduction pathway
Amaravadi et al., J Clin Invest 2005
(Inflammation...) :
The PI3K dependent activation of the
Akt kinases and the
JAK/STAT dependent
induction of the Pim kinases are examples of partially overlapping survival kinase pathways
Sharma et al., Endocr Relat Cancer 2006
(Endometrial Neoplasms...) :
Moreover, leptin induced phosphorylation of ERK2 and
AKT was
dependent on
JAK/STAT activation
El Mabrouk et al., Biochim Biophys Acta 2007
:
Furthermore,
JAK3 inhibition time-dependently
down-regulated Akt but not ERK1/2 phosphorylation suggesting that Akt is a downstream target of JAK3
Saxena et al., Cancer Res 2007
(Carcinoma, Hepatocellular...) :
Leptin induced phosphorylation of ERK and
AKT was
dependent on
Janus activated kinase ( JAK ) /STAT activation
Neilson et al., Mol Endocrinol 2007
(Breast Neoplasms) :
Finally, suppression of
Jak1 by lentiviral delivery of Jak1 short hairpin RNA blocked PRL activation of ERK and signal transducer and activator of transcription ( Stat ) 3 and
suppressed PRL activation of Jak2, Stat5a, Stat5b, and
Akt , as well as tyrosine phosphorylation of PRLR
Wang et al., J Immunol 2011
:
JAK1 activity was
required for IFN-ß to activate PI3K and
Akt1 that resulted in repression of glycogen synthase kinase 3 ( GSK3 ) -ß activity
Li et al., PloS one 2012
(Hypereosinophilic Syndrome) :
Interestingly,
JAK2 inhibition also
reduced PI3K,
Akt and NF-?B activity in a dose dependent manner, and suppressed expression levels of c-Myc and Survivin