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ITGB3 — MAPK3

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MAPK3 → Complex of ITGAV-ITGB3 (increases, ITGAV/ITGB3 Activity, MAPK3 Activity) Rüegg et al., Biochim Biophys Acta 2004*
  Evidence: Activated ERK enters the nucleus to promote transcription [64]. The MAPK pathway is critically involved in controlling proliferation, survival, and migration of endothelial cells. Angiogenesis in the chorio-allantoid membrane (CAM) model requires two waves of ERK activation, the first one being dependent on FGF-2, and the second one on aVh3 integrin ligation [65].
• NCI Pathway Database Integrins in angiogenesis: Erk1-2 (MAPK3/MAPK1) → alphav/beta3 Integrin/JAM-A complex (F11R-ITGAV-ITGB3) (modification, collaborate)
  Naik et al., J Cell Sci 2006
  Evidence: mutant phenotype, assay
• NCI Pathway Database Integrins in angiogenesis: alphav/beta3 Integrin/JAM-A complex (F11R-ITGAV-ITGB3) → Erk1-2-active (MAPK3/MAPK1) (modification, activates)
  Naik et al., J Cell Sci 2006
  Evidence: mutant phenotype, assay
• NCI Pathway Database Integrins in angiogenesis: Erk1-2 (MAPK3/MAPK1) → alphav/beta3 Integrin complex (ITGAV-ITGB3) (modification, collaborate)
  Naik et al., Blood 2003, Eliceiri et al., J Cell Biol 1998
  Evidence: mutant phenotype, assay, other species

Text-mined interactions from Literome

Vellon et al., Mol Carcinog 2006 (Breast Neoplasms...) : Here, we have assessed the role of the extracellular signal regulated kinase ( ERK1 ) /ERK2, mitogen activated protein kinase ( MAPK ), and phospoinositide 3-kinase (PI-3'K) signaling pathways in the expression and function of alpha(v)beta(3) integrin in breast cancer models
Park et al., Reproductive biology and endocrinology : RB&E 2009 (Endometrial Neoplasms) : Thus, in the present study, we further examined the possibility that GnRH induces integrin beta3 and activation of focal adhesion kinase ( FAK ) through mitogen activated protein kinases ( MAPKs ), ERK1/2 and p38, to inhibit the growth of HEC1A endometrial cancer cell line