◀ Back to MAPK3
ITGB3 — MAPK3
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
MAPK3
→
Complex of ITGAV-ITGB3
(increases, ITGAV/ITGB3 Activity, MAPK3 Activity)
Rüegg et al., Biochim Biophys Acta 2004*
Evidence: Activated ERK enters the nucleus to promote transcription [64]. The MAPK pathway is critically involved in controlling proliferation, survival, and migration of endothelial cells. Angiogenesis in the chorio-allantoid membrane (CAM) model requires two waves of ERK activation, the first one being dependent on FGF-2, and the second one on aVh3 integrin ligation [65].
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NCI Pathway Database Integrins in angiogenesis:
Erk1-2 (MAPK3/MAPK1)
→
alphav/beta3 Integrin/JAM-A complex (F11R-ITGAV-ITGB3)
(modification, collaborate)
Naik et al., J Cell Sci 2006
Evidence: mutant phenotype, assay
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NCI Pathway Database Integrins in angiogenesis:
alphav/beta3 Integrin/JAM-A complex (F11R-ITGAV-ITGB3)
→
Erk1-2-active (MAPK3/MAPK1)
(modification, activates)
Naik et al., J Cell Sci 2006
Evidence: mutant phenotype, assay
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NCI Pathway Database Integrins in angiogenesis:
Erk1-2 (MAPK3/MAPK1)
→
alphav/beta3 Integrin complex (ITGAV-ITGB3)
(modification, collaborate)
Naik et al., Blood 2003, Eliceiri et al., J Cell Biol 1998
Evidence: mutant phenotype, assay, other species
Text-mined interactions from Literome
Vellon et al., Mol Carcinog 2006
(Breast Neoplasms...) :
Here, we have assessed the
role of the extracellular signal regulated kinase ( ERK1 ) /ERK2,
mitogen activated protein kinase ( MAPK ), and phospoinositide 3-kinase (PI-3'K) signaling pathways in the expression and function of
alpha(v)beta(3) integrin in breast cancer models
Park et al., Reproductive biology and endocrinology : RB&E 2009
(Endometrial Neoplasms) :
Thus, in the present study, we further examined the possibility that GnRH
induces integrin beta3 and activation of focal adhesion kinase ( FAK ) through mitogen activated protein kinases ( MAPKs ),
ERK1/2 and p38, to inhibit the growth of HEC1A endometrial cancer cell line