Gene interactions and pathways from curated databases and text-mining

◀ Back to MAPK3

ITGB1 — MAPK3

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: MAPK3 → Complex of ITGA5-ITGB1 (increases, ITGA5/ITGB1 Activity) Bao et al., Mol Cell Biol 2002*
    Evidence: Cell attachment to fibronectin through ITGA5.ITGB1 activated the phosphorylation of ERK-1 within 60 minutes. ERK-1 activation was detected even in the presence of dn Cdc42 or dn Rac1 after attachment to fibronectin, indicating that these integrin-induced signaling components are still activated by attachment when Cdc42 and Rac1 are blocked.

Text-mined interactions from Literome

Shin et al., Mol Cells 1999 : These results suggest that the overexpression of alpha3beta1 integrin and the constitutive activation of Erk1/2 play a key role in the alteration of the angiogenic properties of ECV304 cells
Qiang et al., Exp Hematol 2000 : Activation of mitogen activated protein kinase through alpha5/beta1 integrin is required for cell cycle progression of B progenitor cell line, Reh, on human marrow stromal cells
Bhowmick et al., J Biol Chem 2001 : Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity ... In summary, TGF-beta mediated p38MAPK activation is dependent on functional integrin beta(1) , and p38MAPK activity is required but is not sufficient to induce EMT
Sato et al., Cancer Res 2005 (Lymphoma, Large B-Cell, Diffuse...) : CD26 regulates p38 mitogen activated protein kinase dependent phosphorylation of integrin beta1 , adhesion to extracellular matrix, and tumorigenicity of T-anaplastic large cell lymphoma Karpas 299 ... Moreover, our data showing that the p38MAPK inhibitor SB203580 dephosphorylates integrin beta1 and that binding of the anti-CD26 antibody 202.36 dephosphorylates both p38MAPK and integrin beta1 on Karpas 299, leading to loss of cell adhesion to the extracellular matrix, indicate that CD26 mediates cell adhesion through p38MAPK dependent phosphorylation of integrin beta1
Camacho-Leal et al., J Cell Physiol 2007 (MAP Kinase Signaling System) : Inhibition of PI3-K and ILK, but not MAPK , prevented the alpha5beta1 integrin activation
Reyes-Reyes et al., Exp Cell Res 2008 (Adenocarcinoma...) : We have previously shown that P-selectin binding to Colo-320 human colon carcinoma cells induces specific activation of the alpha(5)beta(1) integrin with a concomitant increase of cell adhesion and spreading on fibronectin substrates in a phosphatidylinositol 3-kinase (PI3-K) and p38 MAPK dependent manner